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Ki-67表达及幽门螺杆菌感染在阿司匹林相关性胃黏膜病变中的作用 被引量:3

Effect of Ki-67 expression and Helicobacter pylori in aspirin associated gastric mucosa injury diseases
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摘要 目的探讨Ki-67表达及幽门螺杆菌(Helicobacter pylori,H.pylori)在阿司匹林相关性胃黏膜病变中的作用。方法本组阿司匹林相关性胃黏膜病变患者共136例,根据胃镜下表现分为出血组、溃疡组和胃炎组;所有患者均应用快速尿素酶试验检测、病理组织学Giemsa染色及13C尿素呼气试验将136例阿司匹林相关性胃黏膜病变患者分为H.pylori感染阳性组和阴性组,应用免疫组织化学染色对各组病变的增殖细胞核抗原Ki-67表达进行检测。结果在正常胃黏膜上皮组织Ki-67无表达或呈弱阳性表达,平均染色积分为0.125±0.354。在阿司匹林相关性胃黏膜病变中,出血组胃黏膜上皮组织Ki-67平均染色积分为3.916±1.676;溃疡组胃黏膜上皮组织Ki-67平均染色积分为2.174±1.527;胃炎组胃黏膜上皮组织Ki-67平均染色积分为1.394±0.899。出血组胃黏膜上皮组织Ki-67平均染色积分显著高于溃疡组及胃炎组(P<0.05)。H.pylori感染阳性组胃黏膜上皮组织Ki-67平均染色积分为2.275±1.511,H.pylori感染阴性组胃黏膜上皮组织Ki-67平均染色积分为1.588±1.698。H.pylori感染阳性组胃黏膜上皮组织Ki-67染色积分明显高于H.pylori感染阴性组(P<0.05)。结论阿司匹林相关性胃黏膜病变组织中,阿司匹林和H.py-lori均可导致胃黏膜的损伤,促进胃黏膜上皮细胞增殖。 Objective To explore the effects of Ki-67 expression and Helicobacter pylori(H.pylori) in aspirin associated gastric mucosa injury diseases.Methods According to the result of gastroscopic,136 patients with aspirin associated gastric mucosa injury diseases were divided into three groups: bleeding group,ulcer group and gastritis group.All patients were detected with rapid urease test(RUT),Giemsa stain and 13C-Urease breath test(13C-UBT).According to the results of above tests,the patients were divided into H.pylori infection group and H.pylori non-infection group.The expression of Ki-67 protein was examined in 136 patients with aspirin associated gastric mucosa injury diseases samples by immunohistochemical technique.Results Immunohistochemical stain scores of Ki-67 in normal gastric mucosa was 0.125±0.354.There were 3.916 ±1.676,2.174 ± 1.527 and 1.394±0.899 in immunohistochemical stain scores in bleeding group,ulcer group and gastritis group,respectively.Compared with ulcer group and gastritis group,significant elevated of Ki-67 expression was shown in bleeding group(P0.05).The expression of Ki-67 in the H.pylori infection group was significantly higher than that in the H.pylori non-infection group with immunohistochemical stain scores of 2.275±1.511 and 1.588±1.698,respectively(P0.05).Conclusion Both H.pylori infection and aspirin participated in gastric mucosa injury are associated with proliferation of gastric epithelial cells in aspirin associated gastric mucosa injury diseases.
出处 《胃肠病学和肝病学杂志》 CAS 2012年第4期353-356,共4页 Chinese Journal of Gastroenterology and Hepatology
基金 清华大学裕元医学科研基金资助项目(20240000577)
关键词 阿司匹林相关性胃黏膜病变 幽门螺杆菌 KI-67 Aspirin associated gastric mucosa injury diseases Helicobacter pylori Ki-67
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参考文献16

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共引文献5

同被引文献35

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