摘要
神经激肽B(neurokinkin B,NKB)是速激肽家族的一员,主要通过其受体NK3R发挥作用。NKB及NK3R在神经系统分布广泛。NKB具有使空腔脏器平滑肌收缩、松弛血管、降低平均动脉压、减慢心率、兴奋离体大鼠脊髓神经元及收缩瞳孔括约肌缩小瞳孔等生物学作用。近年来NKB在生殖内分泌中的调控作用越来越受到关注,关于其调节下丘脑-垂体-性腺轴(HPGA)的作用的研究也越来越深入。本文综述了NKB及其受体的分布范围、生理功能、NKB在生殖内分泌调控过程中的作用,其具体的作用机制还有待于进一步研究。
Neurokinkin B（NKB） is a member of tachykinin family and plays a role mainly through its receptor NK3R.NKB and NK3R are wide spread through the neural system.Studies revealed that NKB has kinds of biological functions such as constringing the smooth muscle of hollow viscus,relaxing blood vessels,reducing mean arterial pressure,slowing heart rate,exciting in vitro spinal cord neurons of rats and astringing sphincter pupillae.For the past few years,people pay more and more attentions to the regulating action of NKB on reproductive endocrine and a lot of research are made to discuss the function of NKB in HPGA.This article summarizes the distribution and physiological function of NKB and NK3R,discusses their functions in reproductive endocrine.Future studies will be needed to determine the precise mechanism of NKB.
出处
《生理科学进展》
CAS
CSCD
北大核心
2012年第2期107-110,共4页
Progress in Physiological Sciences
