摘要
目的观察益气活血化痰方对高脂血症兔血脂及高密度脂蛋白亚型的影响。方法采用40只正常雄性新西兰兔,随机分为生理盐水组、高脂血症模型组、阿昔莫司组及益气活血化痰方组,每组10只新西兰兔,给予高脂饮食8周造模。造模成功后分别进行相应干预4周。观察各组兔血脂及高密度脂蛋白亚型的水平。结果实验兔8周时高脂血症模型造模成功,实验12周时,与模型组比较,中药组与西药组胆固醇、甘油三酯及低密度脂蛋白水平显著降低,中药组家兔血Apo-AI水平亦下降,差异有统计学意义(P<0.05);实验12周时与正常组比较,中药组、西药组、模型组,preβ1-HDL水平差异无统计学意义(P>0.05);与模型组比较,中药组与西药组HDL-2水平明显升高,差异有统计学意义(P<0.05)。结论益气活血化痰方能有效降低胆固醇、甘油三酯及低密度脂蛋白,且可上调HDL-2的水平。
Objective To observe the effect of ＂Yiqi Huoxue Huatan Decoction＂（YHHD） on serum lipids and high density lipoprotein subtypes in hyperlipidemic rabbits.Methods Forty male rabbits were randomly divided into control group,hyperlipidemia group,acipimox group and YHHD group,and 10 in Each group were intervened by different methods for 4 weeks.The levels of serum lipids and high density lipoprotein subtypes were observed.Results The hyperlipidemia models were established after 8 weeks then treated for 4 weeks.The cholesterol,triglycerides and low density lipoprotein（LDL） were lower in YHHD group and western medicine group than that of in model group;the Apo-AI level was lower in YHHD group than that of in model group,with significant difference（P0.05）;At 12th weeks,no significant difference was found in preβ1-HDL level among the four groups（P0.05）;the HDL-2 level in YHHD group and western medicine group was higher than that of in model group,with significant difference（P0.05）.Conclusion ＂Yiqi Huoxue Huatan Decoction＂ can low the levels of cholesterol,triglycerides and LDL,and increase the level of HDL-2 effectively.
出处
《上海中医药杂志》
2012年第4期73-75,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市医学重点专科项目(05-II026)
上海市普陀区科委自主创新项目
关键词
益气活血化痰方
高密度脂蛋白
HDL-2
高脂血症
＂Yiqi Huoxue Huatan Decoction＂
high density lipoprotein
HDL-2
hyperlipidaemia（HLP）
