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肝癌衍生生长因子研究进展 被引量：1

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摘要 肝癌衍生生长因子(HDGF)是该蛋白质家族第一个被发现的成员,具有促进细胞增殖、分化,组织器官生长发育,损伤后组织修复等功能。HDGF与肿瘤发生、发展有关,在肝癌、胃癌、非小细胞肺癌等肿瘤组织中表达增加,HDGF与肿瘤患者预后相关,有望成为肿瘤诊断新的分子标志物及潜在治疗靶点。此文就其研究进展作一简要综述。
作者 纪小微 毛建山
机构地区 浙江大学医学院附属第二医院消化内科
出处 《国际消化病杂志》 CAS 2012年第2期96-98,共3页 International Journal of Digestive Diseases
基金 浙江省自然科学基金(Y2090322)
关键词 肝癌衍生生长因子 功能 肿瘤
分类号 R735.7 [医药卫生—肿瘤]
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参考文献25

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同被引文献42

  • 1谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:118-119.
  • 2Thakar K, Votteler I, Kelkar D, et al. Interaction of HRP-2 isoforms with HDGF: chromatin binding of a specific heteromer [ J ]. FEBS J,2012,279(5) :737-751.
  • 3Huang JS, Chao CC, Su TL, et al. Diverse cellular transformation capability of overexpressed genes in human hepatocellular carci- noma[ J ]. Biochem Biophys Res Commun, 2004,315 ( 4 ) : 950- 958.
  • 4Sue SC, Chen JY, Lee SC, et al. Solution structure and heparin interaction of human hepatoma-derived growth factor [ J ]. J Mol Biol, 2004,343 ( 5 ) : 1365-1377.
  • 5Stec I, Nag! SB, van Ommen GJ, et al. The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? [ J]. FEBS Lett,2000,473 ( 1 ) : 1-5.
  • 6Nameki N, Tochio N, Koshiba S, et aL Solution structure of the PWWP domain of the hepatoma-derived growth factor family [ J ]. Protein Sci ,2005,14(3 ) :756-764.
  • 7Dietz F, Franken S, Yoshida K, et al. The family of hepatoma- derived growth factor proteins: characterization of a new member HRP-4 and classification of its subfamilies[ J]. Biochem J ,2002, 366(Pt 2) :491-500.
  • 8Zhao J, Yu H,Lin L, et al. Interaetome study suggests multiple cel- lular functions of hepatoma-derived growth factor (HDGF) [ J ]. J Proteomics,2011,75 (2) :588-602.
  • 9Lukasik SM, Cierpicki T, Borloz M, et aL High resolution structure of the HDGF PWWP domain:a potential DNA binding domain[ J ]. Protein Sei, 2006,15 ( 2 ) :314 -323.
  • 10Ye F, Cheng Q,Zhou C, et al. Hepatoma-derived growth factor is a novel prognostic factor for cervical squamous cell carcinoma [ J ]. Histopathology ,2011,58 (6) :982-984.

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国际消化病杂志
2012年 第2期

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