摘要
为总结本院42例小儿乙型肝炎病毒相关肾炎(HBV-GN)中表现为肾病综合征(HBV-NS)的临床特点、合并肝脏受损情况并提出诊断标准意见。对42例患儿活检的肾组织进行病理分型、免疫组化检测HBV抗原及原位杂交法检测HB-VDNA。结果:42例HBV-NS中有6例血清HBV感染标志阴性,其肾组织有5例病理类型为膜性肾炎及HBV抗原阳性,6例HBVDNA均阳性,除外了继发性肾小球疾病,最终仍确诊为HBV-NS。故认为肾组织的HBV感染标志较血清HBV感染标志更为重要。通过肾组织中HBV抗原及HBVDNA检测的比较,后者似更为敏感。并提出肾组织HBVDNA的检测应作为诊断HBV-NS的重要依据之一。
To explore the diagnostic criterion for nephrotic syndrome (HBV - NS) induced by hepatitis B associated glomerulonephritis (HBV-GN), clinical features were analyzed in the 42 cases with (HBV-NS). Using immunochemistry and in situ hybridization. HBV antigens and HBV - DNA were detected, respectively. Renal biopsy tissue was also pathologically classified by microscopic examination. The results showed that negative serum markers of HBV infection were found in 6 of 42 cases with HBV - NS,but HBV - DN A in renal tissues were detected in all 6 cases, and 5 of them were identified as membranous nephritis with positive HBV antigen,The six children were finaiiy diagnosed as HBV - NS, and secondary glomerulonephritis was excluded. It is concluded that renal HBV marker seems more important than serum HBV marker, and detection of renal HBV - DNA is more sensitive than renal HBV antigen. It is suggested that detection of HBV - DN A may be one of essential diagnostic criterion for HBV - NS.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2000年第1期11-12,共2页
Journal of Clinical Pediatrics
