期刊文献+

癫癎儿童发作期与稳定期血清细胞因子的变化意义 被引量:2

Changes of cytokine levels of peripheral blood in children with epilepsy of different periods
下载PDF
导出
摘要 目的探讨原发性癫癎患儿治疗前后血清细胞因子白细胞介素-2(IL-2)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平的变化及临床意义。方法采用酶联免疫吸附法(ELISA)对34例癫癎发作期患者、31例治疗稳定期患者及年龄、性别相匹配的35例对照者(正常儿童)血清IL-2、IL-6、TNF-α水平进行测定。结果癫组血清IL-2、IL-6和TNF-α水平均高于对照组,且发作组高于稳定组(P<0.01)。结论癫癎患者的免疫系统处于活化状态,细胞因子水平的失衡参与了癫癎的免疫病理过程。 Objective To investigate the changes of interleukin-2(IL-2),interleukin-6(IL-6) and tumor necrosis factor alpha(TNF-α) in epileptic patients of different periods,and to definite their roles in the pathogenesis of epilepsy.Methods Serum contents of IL-2,IL-6 and TNF-α were determined by ELISA in 34 epilepsy patients of onset and 31 stable phase epilepsy patients,and 35 healthy children with regard to age and sex as control.Results The levels of all three cytokines were significantly higher in epileptic group than that of control group,and epileptic patients on the period of onset were significantly higher than those patients in the stable phase(P0.01).Conclusion The immune system of children with epilepsy is in an activated state.The imbalance of cytokines level may be involved in immunopathologlogy of epilepsy.
出处 《中国实用神经疾病杂志》 2012年第5期18-20,共3页 Chinese Journal of Practical Nervous Diseases
基金 青岛市公共领域科技支撑计划资助项目(08-2-1-2-nsh)
关键词 癫癎 白细胞介素-2 白细胞介素-6 肿瘤坏死因子-Α Epilepsy Interleukin-2 Interleukin-6 Tumor necrosis factor-α
  • 相关文献

参考文献9

  • 1张其梅,夏杰,彭玉.细胞因子与缺血性脑卒中[J].中国实用神经疾病杂志,2010,13(19):73-74. 被引量:23
  • 2Gampell IL,Oldstone MBA,Mucke L,et al.Neurologic dis-ease induced in transgenic mice by the astrocyte-specific expres-sion of IL-6[J].Soc Neurosci Abstr,1992,18(1):206-211.
  • 3Lehtimaki KA,Keramen T,Palmio J,et al.Increased plasmalevels of cytokines after seizures in localization-related epilepsy[J].Acta Neurol Scand,2007,116(4):226-230.
  • 4Muller M,Fontana A,Zbinden G,et al.Effects of interferonsand hydrogen peroxide on CA3pyramidal cells in rat hippocam-pus slice cultures[J].Brain Res,1993,619(1/2):157-162.
  • 5许忠,郑百红,毓明涛,蓝继毓,孙丹枫,张睿鹏.白细胞介素-2及免疫球蛋白治疗小儿难治性癫痫临床应用[J].中国妇幼保健,2005,20(4):478-480. 被引量:3
  • 6Ravizza T,Rizzi M,Perego C,et al.Inflammatory responseand glia activation in developing rat hippocampus after statusepileptics[J].Epilepsia,2005,46:113-117.
  • 7De Simoni MG,Perego C,Ravizza T,et al.Inflammatory cy-tokines and related genes are induced in the rat hippocampus bylimbic status epileptics[J].Eur J Neurosci,2000,12(7):2623-2 633.
  • 8刘澄,彭德胜,田根胜.癫痫患者外周血IL-8、IL-10、TNF-α水平的变化及临床意义[J].实用预防医学,2010,17(6):1201-1202. 被引量:5
  • 9Sinha S,Patil SA,Jayalekshmy V,et al.Do cytokines haveany role in epilepsy[J].Epilepsy Res,2008,82(2/3):171-176.

二级参考文献39

  • 1陈旭勤,王浙东,包关水.电点燃癫痫大鼠海马TNF-α和IL-6 mRNA表达的实验研究[J].山东医药,2005,45(10):26-27. 被引量:1
  • 2Lorenz R. Clinical study: epileptic seizures may modify cytokine secretion in patients suffering from epilepsy and in experimental animals[J]. Neumendocrinol Lett,2001,22(5) :330 - 331.
  • 3Maroder M, Beuavia D, Vaeca A, et al. The thymus at the Crossroad of flcuro immune interactions[J]. Ann N Y Aead Sci, 2000,917:741 - 747.
  • 4Vezzani A, Moneta D, Richichi C, et al, Functional role of in Sammato - ry cytokines and antiinflammatory molecules in seizures and epileptogensis [ J ]. Epilepsia, 2002,43 ( 5 ) : 30 - 35.
  • 5Zhang Y, Pileggi, Antonello, et al. Adeno - associated virus - mediated IL- 10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice[J ]. Diabetes, 2003.
  • 6Mattson MP, rnlandola S. NF- KB in the neuronal plasticity and neurodegenerative disorders[ J ]. Clin Invest, 2001,107(3) :247 - 254.
  • 7Mulier M, Fontana A, Zbinden G, et al. Effect of interferons and hydrogen peroxide of CA3 pyramidal cells in rat hippocampal slice cultures[ J ]. Brain Res, 1993,613 (1) : 157.
  • 8Simon M, Moniea CP, Ena W, et al. The dual role of IL- 10[J], Trends in Immunol, 2005,24( 1 ) : 36 - 43.
  • 9Mao M, H ua Y,Jiang X, Li L, et al. Expression of tumor necrosis factor alpha and neuronal apoptosis in the developing rat brain after neonatal stroke[J]. Neurosci Lett, 2006,403:227- 232.
  • 10Rodriguez-Ya? ez M, Castillo J. Role of inflammatory markers in brain ischemia[J]. Curr Opin Neurol,2008,21:353-357.

共引文献28

同被引文献25

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部