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骨转换生物标记物在乳腺癌骨转移瘤疗效评价与监测中的作用 被引量:1

The efficacy of bone turnover biomarkers in evaluation and monitoring in breast cancer bone metastases
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摘要 骨转换生物标记物是近年来探索用于骨转移瘤疗效评价及监测的新方法.这些存在于骨转移患者血液及尿液中的生物标记物让我们更深入了解骨破坏的过程及骨骼与肿瘤之间的相互作用.本文旨在通过回顾常用骨生物标记物在骨转移瘤治疗与监测的相关研究,探讨其潜在的临床价值. Biomarkers of bone turnover is a new method of evaluation and monitoring in bone metastases. The biomarkers in blood and urine may allow us to better understand the process of bone destruction and the interaction between skeletal and tumor. The aim of our article is to explore the potential clinical value by reviewing commonly used biomarkers of bone metastases in treatment and monitoring.
机构地区 军医进修学院
出处 《实用肿瘤学杂志》 CAS 2012年第2期154-157,共4页 Practical Oncology Journal
基金 国家青年科学基金项目(30901455)
关键词 骨生物标记物 NTX BALP 疗效评价 监测 Bone biomarkers BALP NTx Evaluation Monitoring
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参考文献23

  • 1Coleman RE. Clinical features of metastatic bone disease and risk of skeletal morbidity [J]. Clin Cancer Res, 2006, 12:6243 - 6249.
  • 2江泽飞,于世英,孙燕.恶性肿瘤骨转移及骨相关疾病临床诊疗专家共识(20LO年版)[M].北京;北京大学医学出版社,2010,47-55.
  • 3Catherine H, Van Poznak, Sarah Temin, et al. American so- ciety of clinical oneology executive summary of the clinical practice guideline update on the role of bone - modifying a- gents in metastatic breast cancer[ J]. J Clin Oncol,2011,29 (9) :1221 - 1227.
  • 4Fizazi K, Lipton A, Mariette X. et al. Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after in- travenous bisphosphonates [J]. J Clin Oncol, 2009, 27 (10) : 1564 - 1571.
  • 5Coleman RE. The clinical use of bone resorption markers in patients with malignant bone disease [ J ]. Cancer, 2002,94 (10) :2521 - 2533.
  • 6Guise TA, Mohammad KS, Clines G, et al. Basic mecha- nisms responsible for osteolytic and osteoblastic bone metas- tases [ J]. Clin Cancer Res,2006,12:6213 - 6216.
  • 7Seibel MJ. Clinical use of markers of bone turnover in meta- static bone disease[ J]. Nat Clin Pract Oncol,2005,2(10) : 504 -517.
  • 8Hegele A, Wahl HG, Varga Z, et al. Biochemical markers of bone turnover in patients with localized and metastasized prostate cancer[J]. BJU Int,2007 ,99 :330 - 334.
  • 9Lipton A, ChapmanJW, Demers L, et al. Elevated bone turn- over predicts for bone metastasis in postmenopausal breast cancer:Results of NCIC CTG MA. 14 [ J]. J Clin Oncol, 2011,29 (27) : 3605 - 3610.
  • 10Smith MR, Cook R J, Coleman R,et al. Predictors of skeletal complications in men with hormone - refractory metastatic prostate cancer [ J ]. Urology,2007,70 (2) : 315 - 319.

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