摘要
目的探讨HER2、MMP2和Leptin在结直肠癌组织中的表达及临床意义。方法选取手术切除并经病理证实的结直肠癌标本85例作为实验组,另取85例相应癌旁正常组织作为对照组。采用免疫组化S-P法测定癌组织、癌旁正常组织中HER2、MMP2和Leptin的表达水平。结果 (1)HER2、MMP2和Leptin在85例结直肠癌组织中均有不同程度的表达:HER2阳性率为29.4%(25/85),MMP2阳性率为72.9%(62/85),Leptin阳性率为78.8%(67/85)均明显高于85例癌旁正常组织中的7.1%(6/85)、16.5%(14/85)和20.0%(17/85),差异有统计学意义(P<0.01);(2)HER2、MMP2和Leptin三者表达水平均与肿瘤的浸润深度、淋巴结转移及Dukes分期呈正相关,统计学显示有差异(P<0.05);(3)HER2、MMP2和Leptin三者阳性组术后1、3和5年生存率均低于阴性组术后生存率,有统计学意义(P<0.05)。结论 HER2、MMP2和Leptin在结直肠癌组织中高表达,与肿瘤的生长、浸润和转移密切相关;HER2、MMP2和Leptin阳性组较低阴性组预后差。
Objective To investigate the expression and clinicopathological significance of HER2,MMP2 and Leptin in tissues of colorectal carcinoma.Methods The experimental group consisted of 85 cases of colorectal cancer specimens pathologically confirmed.Meanwhile,85 cases of normal tissues taken from the corresponding area around the cancer were treated as the control group.The immunohistochemical SP method was used to detect the expression of HER2,MMP2 and Leptin in carcinomatous tissue and adjacent normal tissue.Results HER2,MMP2 and Leptin positive stained were detected more or less in all of the 85 cases.Positive expression of HER2,MMP2 and Leptin were found 29.4%（25/85）,72.9 %（62/85） and 78.8%（67/85） in colorectal carcinoma,significantly higher than 7.1%（6/85）,16.5%（14/85） and 20.0%（17/85） in 85 cases adjacent normal tissues evidently（P0.01）.The expression of HER2,MMP2 and Leptin is positively associated with the depth of tumor invasion,lymph node metastasis and Dukes stage（P0.05）.The postoperative 1-,3-,5-year overall survival for positive groups of HER2,MMP2 and Leptin significantly lower than negative groups（P0.05）.Conclusion MMP2,HER2 and Leptin are significantly expressed in the tissues of colorectal carcinoma,and closely associated with the growth,invasion and metastasis of tumors.The positive groups of MMP2,HER2 and Leptin have a worse prognosis than the negative groups.
出处
《安徽医药》
CAS
2012年第4期479-482,共4页
Anhui Medical and Pharmaceutical Journal
