摘要
多肽类药物在体内的半衰期较短,是影响其成药性的主要因素,因此解决这一问题成为多肽能否成药的关键。对延长多肽类药物在体内半衰期的化学修饰方法的原理和目前的研究现状进行综述。
Short half-time is the main factor that restricts peptides becoming effective drugs. To solve this problem is the key for peptides to change into drugs. The research of peptide drugs long-acted technology and long-acting peptide drugs has turned into a new and hot field, causing wide concern The paper summarized the chemical modification methods about prolonging peptide drugs half-life, in- cluding their principle and present research situation.
出处
《重庆理工大学学报（自然科学）》
CAS
2012年第4期33-39,共7页
Journal of Chongqing University of Technology：Natural Science
基金
国家"十一五"科技重大专项资助项目(2009ZX09401-004)
关键词
多肽
长效
化学修饰
peptide
long-acting
chemical modification
