摘要
【目的】探讨13C尿素呼气试验(13C-urea breath test,13CUBT)作为消化道幽门螺旋杆菌检测的首选方法,以及有效根除幽门螺旋杆菌的治疗方案。【方法】在我中心门诊11个月共收集321例消化道疾病的患者,每例患者均采用13CUBT(研究组)和胶体金免疫层析法(gold colloid immunochromatographic method,GICA,对照组)检测幽门螺旋杆菌(helicobacter pylori,Hp)的感染,然后比较2种检测方法的结果。对13CUBT阳性患者使用改良(早晚空腹服药,2周疗程)的三联法(质子泵抑制剂+抗菌素)与四联法(质子泵抑制剂+抗菌素+枸橼酸铋剂)治疗与跟踪方案。【结果】13CUBT组和GICA组检测阳性率为经配对χ2检验后,差异有统计学意义(χ2=130.7,P<0.05)。三联法的Hp根除率达84%,四联法Hp累计根除率达95%以上。【结论】13CUBT的敏感性显著高于胶体金免疫层析法,是理想的检测Hp感染的首选方法。改良的治疗方案对Hp的根治有非常满意的效果。
【Objective】To explore the preferred method for detection of helicobacter pylori（Hp） infection and treatment scheme of effective eradicating helicobacter pylori.【Method】321 patients with digestive tract disease were collected in 11 months at center clinic,and Hp infection were tested for every patient by 13C breath test for the study group and colloidal gold immune chromatography method for the control group,then detecting results of two methods were compared.The improved（fasting medication,two weeks treatment） treatment and tracking scheme of triple method（proton pump inhibitors ＋ antibiotics） and tetrad method（proton pump inhibitor ＋ antibiotic ＋ bismuth citrate agent） were used to the patient of 13C breath test【.Results】Positive rate of 13C breath test for the study group and colloidal gold immune chromatography method for the control group were statistically significant differences（χ2= 130.7,P〈0.05） after paired chi-square test.The eradication rate of triple method was 84% and tetrad method was above 95%.【Conclusions】The sensitivity of 13C breath test is higher than that Colloidal gold immune chromatography method,and 13C breath test is the preferred method for detection of Hp infection,and the improved scheme of Hp radical have very satisfactory results.
出处
《武警医学院学报》
CAS
2012年第4期263-265,共3页
Acta Academiae Medicinae CPAPF
