摘要
目的观察利多卡因在全麻诱导中预防芬太尼呛咳反应的效果。方法选择60例ASAⅠ～Ⅱ级、年龄28～65岁的择期手术患者,将其随机分为两组。A组为对照组,实验药物为生理盐水5 ml,B组为实验组,实验药物为利多卡因1.5 mg/kg,两组药物分别在全麻诱导前1min给予。观察芬太尼引发呛咳的发生率及诱导期血流动力学的变化。结果两组呛咳的发生率分别为:A组47%,B组13%。B组呛咳发生率明显降低,两组比较,差异有统计学意义(P<0.05),但诱导前后血流动力学的变化一致。结论应用利多卡因可以有效地降低全麻诱导期芬太尼引发的呛咳反应。
Objective To evaluate the clinical effect of Lidocaine on irritating cough caused by Fentanyl in general anesthesia induction.Methods 60 cases of ASA I～II patients aged from 28～65 undergoing operation randomly received treatment with 5ml physiological saline（group A;n=30） or 1.5 mg/kg Lidocaine（group B;n=30） one minute before Fentanyl was given,and the incidence of irritating cough and hemodynamic changes in patients were evaluated in anesthesia induction period.Results The occurrence of irritating cough in group B（13%） was significantly lower than that in group A（47%）,the difference showed statistical significance（P〈0.05）.And no difference was observed in hemodynamic changes between both groups.Conclusion Lidocaine may is an effective way to prevent the occurrence of irritating cough caused by Fentanyl in general anesthesia induction.
出处
《临床军医杂志》
CAS
2012年第1期86-87,共2页
Clinical Journal of Medical Officers
关键词
利多卡因
芬太尼
呛咳
Lidocaine
Fentanyl
irritating cough
