摘要
TRIM（tripartite motif）蛋白是一类含有RING结构域的蛋白质,在人类中发现超过70种,还有许多新成员正在研究中.这类蛋白除了参与细胞增殖、分化、发育、形态发生和细胞凋亡.也在免疫相关信号通路和抗病毒免疫反应中发挥重要作用.TRIM25能够泛素化病毒RNA受体视黄酸诱导基因-Ⅰ（RIG-Ⅰ）的N末端,这种改变能够激活RIG-Ⅰ与其下游配体结合参与线粒体抗病毒信号通路（MAVS）.这个过程直接引起I型干扰素（IFN）的产生从而抑制病毒复制.近来的研究发现甲型流感病毒能够靶向结合TRIM25,使其抗病毒的功能失效从而抑制宿主的干扰素活性.本文对TRIM蛋白在抗病毒防御机制中的功能以及一种流感病毒通过靶向结合某种TRIM蛋白而产生的免疫逃逸机制的研究进展进行总结.
TRIM （tripartite motif） proteins are a family of RING domain - containing proteins comprising more than 70 members in human, with new members still being described. They are not only in- volved in cell proliferation, differentiation, development, morphogenesis, and apoptosis, but also in immune signaling and antiviral functions. TRIM25 can ubiquitinate the N terminus of the viral RNA receptor retinoic acid - inducible gene-I （RIG-I） , and this alteration is essential for RIG-I to interact with its downstream partner mitochondrial antiviral signaling （MAVS）. This activity of TRIM25 will lead to the activation of the RIG-I signaling pathway, which results in type I interferon production to limit viral replication. Recently, it has been demonstrated that influenza A viruses can target TRIM25 and disable its antiviral function, thus suppressing the host interferon response. In this article, we highlight the emerging roles of TRIM proteins in antiviral defense mechanisms and an immune evasion strategy in which influenza viruses target a member of the TRIM family.
出处
《国际病毒学杂志》
2012年第2期57-60,共4页
International Journal of Virology
基金
山东省自然科学基金重大项目ZR2011HZ004山东省高等学校科学计划项目基金J10LC21
