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系统性红斑狼疮患者血清中IL-17的检测及临床意义 被引量:2

The Detection and Clinical Significance of Serum IL-17 in Patients with Systemic Lupus Erythematosus
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摘要 目的:通过检测系统性红斑狼疮(SLE)患者外周血中IL-17的水平,探讨其临床意义。方法:用酶联免疫吸附法(enzymelinked immunosorbent assay,ELISA)检测61例SLE患者及30例健康人血清IL-17水平,并收集整理SLE患者的临床资料及实验室数据,分析其与临床的关系。结果:活动期SLE患者血清IL-17水平明显高于正常对照组(P<0.01),与SLE非活动组相比,差异亦有统计学意义(P<0.01)。但SLE非活动组与正常对照组间无统计学意义。结论:IL-17水平在活动期SLE患者血清中表达明显增高,且与SLEDAI评分呈正相关,提示IL-17可能参与了SLE疾病的病理过程,可能与疾病活动的关系密切。 Objective:To analyze the levels of interleukin 17(IL-17)in the peripheral blood of patients with SLE,and to investigate the clinical significance.Methods: IL-17 levels were assessed in 61 SLE patients and 30 normal controls by enzyme-linked immunosorbent assay(ELISA).And the clinical and laboratory data of the patients were collected.To explor the relationship between IL-17 and clinical of SLE patients.Results: The plasma concentration of IL-17 was significantly elevated in SLE patients as compaired to the normal control group(P〈0.01).Compared with patients wi th inactive SLE,the levels of IL-17 had the statistic differences,and there showed no statistic differences between patients with inactive SLE and normal controls.Conclusion: IL-17 in the sera of untreated SLE patients is significantly higher,and the levels of them are positively correlated with SLEDAI scores.The results suggest that IL-17 may play an important role in the pathogenesis of SLE,especially in active SLE.
机构地区 潍坊医学院
出处 《现代生物医学进展》 CAS 2012年第9期1704-1706,共3页 Progress in Modern Biomedicine
关键词 系统性红斑狼疮 白介素17 系统性红斑狼疮疾病活动性指数 酶联免疫吸附 Systemic lupus erythematosus; Interleukin-17; SLEDAI; Enzyme linked immunosorbent assay;
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