摘要
快速老化小鼠 (Senescenceacceleratedmouse,SAM)分为快速老化亚系 (Senescenceacceleratedmouse/ prone,SAMP)及抗快速老化亚系 (Senescenceacceleratedmouse/re sistance ,SAMR)。由日本京都大学首次培育成功 ,目前共有12个亚系 ,不同亚系具有不同的病理表现型 ,其中许多具有与人类衰老相似的病理学特征。人类许多老年性疾病如肺泡扩张、骨质疏松、骨关节疾病、学习记忆功能障碍、情感紊乱 (抑郁 )、白内障、听觉障碍、脑萎缩、免疫缺陷等在SAMP不同亚系上均有不同程度的体现 ,而SAMR亚系的各项生理指标及生存期限与正常动物相似。因此 ,SAM (SAMP、SAMR)为探讨衰老及衰老相关疾病的发生机制 ,评价药效及其作用机制提供了良好的动物模型。
The Senescence accelerated mouse(SAM),consisting of nine Senescence accelerated mouse/prone(SAMP) strains and three senescence accelerated mouse/resistance(SAMR) strains, has been first developed at Kyoto University. It became evident that SAMP strains manifest various pathologic phenotypes that are characteristic enough to differentiate the SAM strains. Many of their pathologic phenotypes are similar to those of human senescence, such as senile osteoporosis, cataract, brain atrophy,deficits in learing and memory, emotional disorder and so on. Therefore, SAM(SAMP,SAMR) provides a good model for clarifing the pathogenic mechanism of senescence and senescence related disease, and evaluating the efficiency of drugs and their mechanisms.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2000年第2期132-137,共6页
Chinese Pharmacological Bulletin
基金
国家"九五"攀登计划预选项目
国家自然科学基金重点项目 !No39830450
关键词
快速老化小鼠
衰老
动物模型
senescence accelerated mouse (SAM)
senescence
murine model
