摘要
目的探讨经阴道超声监测激素治疗对绝经过渡期和绝经期妇女子宫及卵巢的影响及其临床应用价值。方法 206例绝经过渡期和绝经期妇女根据治疗方法分为绝经期激素治疗组(A组)、绝经期安慰剂治疗组(B组)、绝经过渡期激素治疗组(C组)及绝经过渡期安慰剂治疗组(D组)。使用经阴道超声观察其子宫体积、内膜厚度及卵巢面积的变化。结果①治疗后,各组子宫体积均呈萎缩趋势(P<0.01),A组萎缩速度较B组明显减慢;②A、B组治疗前后子宫内膜大小比较,差异无统计学意义,C、D组治疗后子宫内膜明显萎缩,与治疗前比较差异有统计学意义(P<0.01);③治疗前后A、C组卵巢面积比较差异无统计学意义,B、D组卵巢面积明显萎缩,差异有统计学意义(P<0.05)。结论长期小剂量激素治疗可降低妇科肿瘤的发生率,激素治疗期间利用超声密切监测子宫及卵巢结构的变化是一种简便、可靠的方法。
Objecive To investigate the effects of hormone therapy on uterus and overies in perimenopausal and transition period women by transvaginal ultrasound, and evaluate its clinical value. Methods Two hundred and six women in postmenopausal and transition period were divided into postmenopausal hormone therapy group （A group）, postmenopausal placebo therapy group （B group ）, postmenopausal transition hormone therapy group （C group） and postmenopausal transition placebo therapy group （D group） according to different treatment method. The changes of uterine volume, endometrial thickness and ovarian area were observed by transvaginal ultrasound. Results After treatment, the uterine volume showed a trend of atrophy in each group（P 〈 0.01 ）, it was more slowly in A group than in B group. There was no significant difference of uterine endometrial thickness between A, B group before and after treatment, while after treatment, the endometrium was shrinked obviously in C, D group, there was significant difference（P 〈 0.01 ）. There was no significant difference of ovarian area in A, C group, while the overy was shrinked obviously in B, D group, there was significant difference（P 〈 0.05）. Conclusion Long-term and low-dose hormone therapy has no obvious effect on incidence of carcinoma of uterus and overies. Ultrasonography is a simple and reliable method to monitor the uterus and overies during hormone therapy.
出处
《临床超声医学杂志》
2012年第4期247-249,共3页
Journal of Clinical Ultrasound in Medicine
关键词
超声检查
经阴道
子宫
卵巢
激素治疗
Uhrasonography, transvaginal
Uterus
Overy
Hormone therapy
