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间皮细胞检测在胸腔积液诊断中的临床应用

Clinical application of pleural mesotheHal cell determination in the diagnosis of pleural effusion
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摘要 目的探讨间皮细胞检测在胸腔积液诊断中的临床应用。方法对36例恶性胸腔积液患者(恶性组)和24例良性胸腔积液患者(良性组)胸腔积液进行间皮细胞检测,判定其在良、恶性胸腔积液中的诊断价值。结果恶性组未出现间皮细胞消失病例,间皮细胞所占百分比〈1%者1例(2.78%),1%-5%者1例(2.78%),〉5%者34例(94.44%)。良性组11例(45.83%)未发现问皮细胞,间皮细胞所占百分比〈1%者8例(33.33%),1%-5%者2例(8.33%),〉5%者3例(12.50%)。两组间皮细胞所占百分比比较差异有统计学意义(r=43.4069,P〈0.01)。良、恶性组间皮细胞所占百分比95%可信区间分别为0.28%-5.10%、5.13%-10.91%,两组可信区间没有相互重叠,因此以胸腔积液间皮细胞所占百分比〉5%作为鉴别良、恶性胸腔积液的标准,其敏感度为94.44%(34136)、特异度为87.50%(21/24)、准确度为91.67%(55^60)。结论间皮细胞所占百分比是一种简单、易行、经济、快捷诊断良、恶性胸腔积液的方法,具有较高的敏感度、特异度和准确度,在临床诊断中有一定的参考价值。 Objective To explore the clinical application of pleura] mesothelial cell (PMC) determination in the diagnosis of pleura[ effusion. Methods PMC of 36 patients with malignant pleural effusion (malignant group) and 24 patients with benign pleura] effusion (benign group) were counted to determine the clinical value of PMC in benign and malignant pleura] effusion. Results In malignant group, there was no case with PMC disappear, 1 case (2.78%) with the percentage of PMC between 0 and 1%,1 case(2.78% ) between 1% and 5%, 34 cases (94.44%) more than 5%. In benign group, there were 11 cases(45.83%) with PMC disappear, 8 cases (33.33%) with the percentage of PMC between 0 and 1%, 2 cases (8.33%) between 1% and 5%, 3 cases( 12.50% ) more than 5%. The percentage of PMC between two groups had significant difference ( A~ =43.4069,P 〈0.01). 95% confidence intervals of PMC in benign and malignant group respectively were 0.28% - 5.10% and 5.13% - 10.91% ,which did not overlap. The percentage of PMC more than 5% was defined as the diagnosis standard of identifying benign and malignant pleural effusion,the sensitivity of the diagnosis was 94.44%(34/36),the specificity was 87.50%(21/24) and the accuracy was 91.67%(55/60). Conclusions PMC determination is a kind of easy ,economical and fast way to diagnose benign and malignant pleural effusion with high sensitivity,specificity and accuracy. Therefore, it has reference value in clinical diagnosis.
作者 李艳丽
出处 《中国医师进修杂志》 2012年第13期24-25,共2页 Chinese Journal of Postgraduates of Medicine
关键词 胸腔积液 间皮细胞 诊断 鉴别 Pleural effusion Mesothelial cell Diagnosis,differential
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