摘要
目的 探讨理想的骨组织工程细胞外基质材料的选择和制备。方法 广泛查阅了近期有关可降解聚合物用作成骨细胞培养支架的文献 ,总结了各种可降解聚合物在骨组织工程研究中作为细胞外基质材料的优缺点。结果 理想的骨组织工程细胞外基质材料应由无机类材料、人工合成聚合物类材料和天然聚合物类材料组成 ,并含有最佳的生长因子缓释系统的多孔三维立体泡沫。结论 复合型细胞外基质材料的研制是骨组织工程研究中十分重要而迫切的任务。
Objective\ To investigate the selection and manufacture of ideal extracellular matrix materials in bone tissue engineering. Methods\ The recent literatures about biodegradable polymers served as culture scaffolds of osteoblasts were widely reviewed, the advantages and disadvantages of biodegradable synthetic polymers and natural polymers were analysed. Results\ The ideal extracellular matrix material in bone tissue engineering should be made up of inorganic materials, synthetic polymers and natural polymers, which posseses morphological structure of three dimensional foam with self mediated drug slow delivery system of bone growth factors. Conclusion The design and manufacture of combined extracellular matrix materials in bone tissue engineering is a very important and urgent challenge.
出处
《中国修复重建外科杂志》
CAS
CSCD
2000年第3期175-180,共6页
Chinese Journal of Reparative and Reconstructive Surgery
关键词
可降解聚合物
骨组织工程
细胞外基质材料
Biodegradable polymers Bone Tissue engineering Extracellular matrix materials
