摘要
目的探讨可吸收泪点栓治疗准分子激光原位角膜磨镶术（LASIK）前伴干眼症患者的效果。方法前瞻性随机双肓对照研究。选取行LASIK术治疗，术前伴轻、中度干眼症的患者41例，同一患者的两眼随机分组，一眼采用可吸收泪点栓结合药物治疗（试验组），另一眼采用单纯药物治疗（对照组）。记录泪点栓的并发症，比较两眼LASIK术前，术后1周和1、3、6个月时泪液分泌试验（SIT）、角膜荧光素染色（FL）、泪膜破裂时间（BUT）和眼表疾病评分（OSDI）的值。运用两相关样本的非参数检验方法（Two Related SamplesTest）进行数据分析。结果除1例患者术后第1天泪点栓脱落外，未见其他并发症。术后1周，试验组的SIT值高于对照组，差异有统计学意义（Z=-2．005，P=0．045），术后1个月及以后，两组的SIT值趋于一致。术后1周、1个月和3个月，试验组的FL值均低于对照组，差异有统计学意义（Z=-2．124、-2．009、-2．120，P〈0．05）。而两组的OSDI和BUT值在上述各时间点差异均没有统计学意义。结论可吸收泪点栓是治疗LASIK术前伴干眼症患者的安全有效的方法。
Objective To evaluate the efficacy of using an absorbable punctal plug in the treatment of preoperative dry eye after laser in situ keratomileusis （LASIK）. Methods This was a prospective, randomized, double-blind study. Forty-one consecutive patients with mild to moderate dye eye were included. Absorbable punctal plugs were randomly implanted in one eye of each patient. Fluorescent staining （FL）, break-up time （BUT）, Sehirmer I test （SIT） and ocular surface disease index （OSDI） grading were performed befbre and 1 week and 1, 3, and 6 months after LASIK. Results No complications were observed except plug extrusion in one ease. FL staining was significantly lower in the treated eyes compared to control eyes at 1 week （Z=-2.124, P=0.034）, 1 month （Z=-2.009, P=0.045） and 3 months （Z=-2.120, P=0.034） after LASIK. SIT was significantly higher in the control eyes at 1 week after LASIK （Z=-2.005, P=0.045）. Conclusion An absorbable punctal plug is an effective method for treating dry eye patients after LASIK.
出处
《中华眼视光学与视觉科学杂志》
CAS
2012年第4期208-211,共4页
Chinese Journal Of Optometry Ophthalmology And Visual Science
关键词
角膜磨镶术
激光原位
干眼病
泪点栓
治疗结果
对照研究
Keratomileusis,laser in situ
Xerophthalmia
Punetal plug
Treatment outcome
Comparative study
