摘要
目的：探讨炎症及冠状动脉狭窄在不稳定性心绞痛（ＵＡ）发生发展中的作用以及二者的相互关系。 方法：用酶联免疫双抗体夹心（ＥＬＩＳＡ）法测定２０例ＵＡ患者（ＵＡ组），２２例稳定性劳累型心绞痛（ＳＡ）患者（ＳＡ组），以及 ２５例正常人（正常对照组）的血浆可溶性白细胞介素－６受体（ｓＩＬ－６Ｒ）和血小板α颗粒膜蛋白－１４０（ＧＭＰ－１４０）水平。同时对ＵＡ及ＳＡ患者行冠状动脉造影，按积分法评定其冠状动脉狭窄程度，对结果进行统计学分析。 结果：①ＵＡ组患者血浆ＳＩＬ－６Ｒ及ＧＭＰ－１４０水平显著高于ＳＡ组（Ｐ＜０．０５）及正常对照组（Ｐ＜０．００１），而后两组间差异不显著（Ｐ＞０．０５）。②ＳＡ组患者冠状动脉狭窄程度较ＵＡ组严重，差异具有显著性（Ｐ＜０．０５）。③ＵＡ组患者ｓＩＬ－６Ｒ、ＧＭＰ－１４０水平与其冠状动脉狭窄程度间无相关性。 结论：结果显示ＵＡ患者体内存在着炎性反应，可能与其冠状动脉病变的不稳定有关；在判断预后方面，炎性细胞因．子水平的变化较之冠状动脉狭窄可能更为重要。
Objective:To explore the role of inflammation and coronary stenosis in the development of unstable angina(UA). Methods:Plasma levels of soluble interleukin-6 receptor (sIL-6R) and P-selection were determined in 20 patients with UA and 22 patients with stable angina (SA) using enzyme liked immunosorbent assay. Data were compared with 25 normal controls. Coronary angiography was performed in all patients with UA and SA, and the seventy of coronary stenosis was evaluated by a quantitative method. Results:①Plasma levels of sIL-6R and P-selection are significantly higher in patients with UA than those in pa- tients with SA(p<0. 05) and normal controls (p<0. 001),but no difference between the latter two groups(p>0. 05). ②Severe coronary stenosis occurred more common in patients with SA than those with UA(p<0. 05). ③There is no correlation between plasma levels of inflammatory cytokines and seventy of coronary stenosis. Conclusion:The results demonstrate that inflammation may play an important role in the pathogenesis of unstable angina,and the level of inflam-matory cytokines may have a higher prognostic value than the seventy of coronary steno- sis.
出处
《中国循环杂志》
CSCD
北大核心
2000年第2期81-82,共2页
Chinese Circulation Journal
关键词
不稳定性心绞痛
炎性细胞因子
冠状动脉狭窄
Unstable angina
Inflammation
Receptors, Interleukin-6
α-grannle membrane protein 140
