摘要
目的探讨白细胞介素 Ⅱ (IL 2 )和LAK细胞对鼻咽癌 (NPC)放疗后患者细胞免疫功能的影响。方法2 7例放疗后获CR的患者分成2组 :A组 (治疗组 ) ,17例接受IL 2和LAK细胞治疗 ;B组 (对照组 ) ,10例仅予一般治疗。检测两组治疗前后NK活性和CD+ 4/CD+ 8值的变化。结果A组治疗后NK活性和CD+ 4/CD+ 8比值均明显提高 (P <0 .0 5 ) ,B组则无明显变化。结论IL 2和LAK细胞治疗可增加NPC放疗后患者的NK活性 ,对T细胞亚群有调节作用。
ObjectiveTo evaluate the effects of IL 2/LAK cells on the cellular immuno function in patients with nasopharyngeal carcinoma(NPC) after radiotherapy.MethodsTwenty seven patients in complete remission(CR) after radiotherapy were divided into two groups:seventeen patients of Group A were treated with IL 2/LAK cells;while ten patients of Group B(control) with general measures.The blood natural Killer (NK) activity and CD + 4/CD + 8 ratio changes in two groups were detected before and after treatment.ResultsAfter treatment,the NK activity and CD + 4/CD + 8 ratio increased sngnificantly in Group A and were much higher than those of in Group B (P<0.05),whereas no distinct difference was found Group B.ConclusionThis treatment can increase NK activity and regulate T cell subsets in NPC patients after radiotherapy.
出处
《湖南医学》
2000年第2期88-89,共2页
Hunan Medical Journal
关键词
鼻咽癌
放射疗法
IL-2
LAK细胞
免疫功能
nasopharyngeal neoplasms/radiotherapy
immunity,cellular/analysis
interleukin 2/therapy
killer cells,lymphokine activated/therapy
