摘要
目的验证平阳霉素局部注射治疗血管瘤特别是颜面部血管瘤的疗效。方法将平阳霉素 8mg加生理盐水 3～ 5ml溶解后行血管瘤 ( 0 .5× 1.0cm2 ～ 4.0× 5 .0cm2 )内注射至局部肿胀、苍白。若血管瘤面积较大或多发时 ,一次注药未愈者 ,可分次、分点注药 ,每次间隔 1～ 2周 ,直至治愈为止。共治疗 60 8例 ,一般用药总量不超过40mg。结果经 1次注射治愈 3 0 2例 ,2～ 3次注射治愈 2 66例 ,面积最大或多发血管瘤分别经7～ 8次注药后治愈。经 1～ 4年随访 ,总有效率为 95 .1%。结论本方法具有操作简单、疗效显著、并发症少等优点 ,只要使用方法正确 ,治疗后不留畸形 ,特别适于体表中小面积血管瘤的治疗。
ObjcetiveTo confirm the therapeutic effects of blemycin A 5 during its intratumor injection for treatment of hemangioma,especially for the hemangioma on facial region.MethodsA mixture of 8 mg blemycin A 5 and 3～5 ml normal saline was injected intratumorly into hemangioma (0.5×1.0 cm 2～4.0×5.0 cm 2) till local tissue became swollen and pale.In the cases of multiple tumor or tumor with large area,drug was injected in multiple points for several times every 1～2 weeks till tumor was cured.The maximum total dose not exceeded 40 mg.ResultsSix hundred and eight cases were treated totally by this method.three hundred and two cases were cured by one injection;whereas two hundred and sixty six cases underwent 2 to 3 injections.The multiple tumors and the tumors with largest area were cured after 7 to 8 injections.The 1 to 4 years follow up showed that the general effective rate was 95.1%.ConclusionsIntratumor injection of blemycin A 5 is an effective and simple method with less complications,particularly suitable for the treatment of hemangiomas with small to moderate area on the body surface.It would not lead to deformity if the therapy is applied correctly.
出处
《湖南医学》
2000年第2期92-94,共3页
Hunan Medical Journal
关键词
药物疗法
平阳霉素
局部注射
bleomycins
hemangioma/therapy
perfusion,regional
