摘要
目的观察六味五灵片预防抗结核药物致药物性肝损伤的临床疗效。方法选择肺结核患者30例,随机分为治疗组(15例)和对照组(15例),两组均应用"2HRZE(S)/4HR"方案进行抗结核化疗。同时治疗组加用六味五灵片,对照组加用葡醛内酯片,观察两组患者治疗过程中肝损伤发生情况。结果治疗组患者有1例发生肝损伤,对照组患者有4例发生肝损伤,发生率分别为6.7%和26.7%,两组比较差异有显著统计学意义(P<0.01)。结论六味五灵片能有效预防抗结核药物导致的药物性肝损伤。
Objective To observe the preventive effect of Liuweiwuling tablets for anti-TB medications-induced liver injury. Methods Total of 30 patients with pulmonary tuberculosis were randomly divided into the treatment group （n = 15） and control group （n = 15）, all patients received ＂2HRZE（S）/4HR＂ therapeutic schedule. Meanwhile, the treatment group added Liuweiwuling tablets and the control group added glucurolactone tablet. The incidences of liver injury in both groups were observed during the treatment process. Results The incidence of liver injury was 6.7% （1/15） in the treatment group, which was 26.7% in the control group. There was statistically significant differences between the two groups （P 0.01）. Conclusions Liuweiwuling tablets can effectively prevent and treat anti-TB medications-induced liver injury.
出处
《中国肝脏病杂志（电子版）》
CAS
2012年第1期26-28,共3页
Chinese Journal of Liver Diseases：Electronic Version
关键词
六味五灵片
抗结核药
肝损伤
Liuweiwuling tablets
Antitubercular agents
Liver injury
