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慢性脑缺血致脑损伤的机制及治疗研究进展 被引量：10

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摘要 近年来，对慢性脑缺血的研究不断深入，创建并不断改进了慢性脑缺血的动物模型，在其病理学及行为学改变方面获得了一系列的实验和临床证据，为探究慢性脑缺血致脑损伤的机制及临床治疗措施奠定了基础。我们系统介绍了慢性脑缺血的概念、动物模型、脑损伤机制及治疗等方面的实验性新进展。
作者 李国青 任长虹 孟然 吉训明
机构地区 首都医科大学附属北京世纪坛医院神经内科 首都医科大学宣武医院低氧医学研究室
出处 《中华老年心脑血管病杂志》 CAS 北大核心 2012年第5期554-556,共3页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金 国家自然科学基金(30770741) 北京市卫生系统高层次人才基金(2009-03-02)
关键词 脑缺血 脑损伤 细胞凋亡 丙二醛 超氧化物歧化酶
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献10

  • 1余芬,章军建.慢性脑缺血大鼠海马中APE的表达与神经元凋亡的实验研究[J].中华神经医学杂志,2006,5(4):363-365. 被引量：20
  • 2Cai ZY, Yan Y,Sun SQ, et al. Minocycline attenuates cogni tive impairment and restrains oxidative stress in the hippo- campus of rats with chronic cerebral hypoperfusion. Neurosci Bull, 2008,24: 305-313.
  • 3Yao Y, Han DD,Zhang T,et al. Quercetin improves cognitive deficits in rats with chronie cerebral ischemia and inhibits voltage-dependent sodium channels in hippocampal CA1 py- ramidal neurons. Phytother Res, 2010,24 : 136-140.
  • 4Pomytkin NA, Storozheva ZI,Semenova NA. Neuroprotective effect of choline succinate in rats with experimental chronic cerebral ischemia evaluated by cognitive ability tests. Izv Akad Nauk Ser Biol, 2007,2 : 183-187.
  • 5Chen L, Wang H, Zhang Z, et al. DMXB(GTS-21) ameliorates the cognitive deficits in beta amyloid (25-35) injected mice through preventing the dysfunction of alpha7 nicotinic recep tor. J Neurosci Res,2010,88: 1784-1794.
  • 6Cechetti F, Worm PV, Pereira LO, et al. The modified 2VO is chemia protocol causes cognitive impairment similar to that induced by the standard method, but with a better survival rate. Braz J Med Biol Res,2010,43:1178-1183.
  • 7Sharma S, Rakoczy S, Brown Borg H. Assessment ofspatial memory in mice. Life Sci, 2010,87 : 521-536.
  • 8刘晖,章军建,张磊.改良型三血管结扎慢性脑缺血模型大鼠的行为学评价[J].中华行为医学与脑科学杂志,2009,18(11):966-969. 被引量：8
  • 9Cai QY, Chen XS, Zhan XL, et al. Protective effects of catal- pol on oligodendrocyte death and myelin breakdown in a rat model of chronic cerebral hypoperfusion. Neurosci Lett, 2011, 497:22-26.
  • 10Bharti VK, Srivastava RS. Fluoride-induced oxidative stress in rat's brain and its amelioration,by bu{falo(Bubalus bubalis) pineal proteins and melatonin. Biol Trace Elem Res, 2009, 130: 131-140.

二级参考文献10

  • 1Liu PK.DNA damage and repair in the brain after cerebral ischemia[J].Curr Top Med Chem,2001,1(6):483-495.
  • 2Wakita H,Tomimoto H,Akiguchi I,et al.Protective effect of cyclosporin A on white matter changes in the rat brain after chronic cerebral hypoperfusion[J].Stroke,1995,26(8):1415-1422.
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  • 4de la Torre JC,Fortin T,Park GA,et al.Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats[J].Brain Res,1992,582(2):186-195.
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  • 6Sugawara T,Chan PH.Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia[J].Antioxid Redox Signal,2003,5(5):597-607.
  • 7Tanaka K,Wada-Tanaka N,Miyazaki I,et al.Chronic cerebral hypoperfusion induces striatal alterations due to the transient increase of NO production and the depression of glutathione content[J].Neurochem Res,2002,27(4):331-336.
  • 8Kawase M,Fujimura M,Fujimura Y,et al.Reduction of apurinic/apyrimidinic endonuclease expression after transient global cerebral ischemia in rats[J].Stroke,1999,30(2):441-449.
  • 9Angkeow P,Deshpande SS,Qi B,et al.Redox factor-l:an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis[J].Cell Death Differ,2002,9(7):717-725.
  • 10Narasimhan P,Sugawara T,Liu J,et al.Overexpression of human copper/zinc-superoxide dismutase in transgenic animals attenuates the reduction of apurinic/apyrimidinic endonuclease expression in neurons after in vitro ischemia and aft er transient global cerebral ischemia[J].J Neurochem,2005,93(2):351-358.

共引文献26

同被引文献91

引证文献10

二级引证文献71

中华老年心脑血管病杂志
2012年 第5期

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