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自身免疫性肝炎的特异性T淋巴细胞免疫 被引量：1

Role of specific T cells in autoimmune hepatitis
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摘要 自身免疫性肝炎（AIH）是一种器官特异性自身免疫性疾病，以肝组织内T淋巴细胞浸润、高γ球蛋白血症、血清自身抗体阳性、具有人类白细胞抗原（HLA）遗传背景、常伴发其他自身免疫性疾病和对免疫抑制治疗有效为特征。
作者 赵艳 李艳丽 闫惠平
机构地区 首都医科大学附属北京佑安医院自身免疫性肝病研究中心
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2012年第5期333-335,共3页 Chinese Journal of Hepatology
基金 北京市自然科学基金（7111004） 国家自然科学基金（81102265）
关键词 肝炎 自身免疫陛 抗原 T淋巴细胞 免疫 细胞 Hepatitis, autoimmune Antigens T-lymphocytes lmmtality, cellular
分类号 R575.1 [医药卫生—消化系统]
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参考文献24

  • 1Mieli-Vergani G, Vergani D. Autoimmune hepatitis. Nat Rev Gastroenterol Hepatol, 2011, 8: 320-329.
  • 2Zachou K, Riqopoulou E, Dalekos GN. Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease. J Autoimmune Dis, 2004, 1: 2.
  • 3Mizutani T, Shinoda M, TanakaY, et al. Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2. Drug Metab Rev, 2005, 37: 235-252.
  • 4Wies I, Brunner S, Herminger J, et al. Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis. Lancet, 2000, 355: 1510-1515.
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  • 7Tahiri F, Le Naour F, Huguet S, et al. Identification of plasma membrane autoantigens in autoimmune hepatitis type 1 using a proteomics tool. Hepatology, 2008, 47: 937-948.
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  • 9Manns MP, Griffin KJ, Sullivan KF, et al. LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase. J Clin Invest, 1991, 88: 1370-1378.
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二级参考文献14

  • 1丙型肝炎防治指南[J].临床肝胆病杂志,2004,20(4):197-203. 被引量：735
  • 2无.慢性乙型肝炎防治指南[J].实用肝脏病杂志,2006,9(1):8-18. 被引量：825
  • 3赵艳,闫惠平,檀玉芬,冯霞,刘妍,崔丹,马冬梅,李伟华,张海萍.抗可溶性肝抗原/肝胰抗原抗体在自身免疫性肝炎诊断及分型中的意义[J].中华肝脏病杂志,2007,15(4):283-286. 被引量：26
  • 4Ma Y,Bogdanos DP,Hussain MJ,et al.Polyelonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2.Gastroenterology,2006,130:868-882.
  • 5Yeoman AD,Westbrook RH,Al-Chalabi T,et al.Diagnostic value and utility of the simplified International Autoimmune Hepatitis Group (IAIHG) criteria in acute and chronic liver disease.Hepatology,2009,50:538-545.
  • 6Lazaridis KN,Talwalkar JA.Clinical epidemiology of primary biliary cirrhosis:incidence,prevalence,and impact of therapy.JClin Gastroenterol,2007,41:494-S00.
  • 7Fuenger S,Watkins DI,Sette A,et al.Characterization of the peptide-binding specificity of Mamu-B * 17 and identification of Mamu-B * 17-restricted epitopes derived from simian immunodeficiency virus proteins.J Immunol,2002,169:210-219.
  • 8Wies I,Brunner S,Henninger J,et al.Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis.Lancet,2000,355:1510-1515.
  • 9Whiteside TL,Zhao Y,Tsukishiro T,et al.Enzyme-linked immunospot,cytokine flow cytometry,and tetramers in the detection of T-cell responses to a dendritic cell-based multipeptide vaccine in patients with melanoma.Clin Cancer Res,2003,9:641-649.
  • 10Rehermann B,Naoumov NV.Immunological techniques in viral hepatitis.J Hepatol,2007,46:508-520.

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中华肝脏病杂志
2012年 第5期

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