摘要
目的探讨降脂通络软胶囊治疗冠心病心绞痛的疗效及作用机制。方法将98例冠心病心绞痛患者经过2周导入期后,随机分为观察组50例和对照组48例。两组患者均给予抗栓、稳定斑块、钙通道拮抗剂及β受体阻滞剂等常规治疗。观察组加用降脂通络软胶囊,每次2粒,每日3次,口服;对照组加用单硝酸异山梨酯缓释片60mg,每日1次,两组仍有心绞痛发作者,临时含服硝酸甘油片1片。两组疗程均为12周。治疗期间记录患者每天心绞痛或胸闷发作次数以及硝酸甘油用量,并检测治疗前后两组患者血清脂联素(APN)和丙二醛(MDA)水平。结果治疗后两组患者心绞痛或胸闷发作次数和硝酸甘油用量均明显减少,与本组治疗前比较差异均有统计学意义(P<0.01),但组间比较差异无统计学意义(P>0.05)。治疗后,观察组血清APN较治疗前和对照组明显升高(P<0.01),对照组治疗后血清APN水平有所上升,但与本组治疗前比较差异无统计学意义(P>0.05)。治疗后,观察组血清MDA较本组治疗前及对照组均明显降低(P<0.01),对照组治疗后血清MDA亦有下降,但差异无统计学意义(P>0.05)。治疗后观察组患者甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)均较治疗前显著下降(P<0.01);治疗后观察组的TG和高密度脂蛋白胆固醇(HDL-C)较对照组差异有统计学意义(P<0.01)。结论常规治疗的基础上,联合降脂通络软胶囊具有良好的抗心绞痛作用,其作用机制可能与抑制体内炎性反应和氧化应激有关。
Objective To explore the effect and mechanism of Jiangzhi Tongluo Soft Gelatin Capsule（soft gelatin capsule for lowering lipid and freeing the network vessels） on angina pectoris.Methods Ninety-e ight cases of angina pectoris were randomized into the observation group of 50 cases,and con trol group of 48 cases.Both groups were given the conventional therapy including antithrombotic therapy,stabling plague,calcium antagonists,β-receptor blocker,while Jiangzhi Tongluo Soft Gelatin Capsule and isosorbide mononitrate table t was added in the observation group and the control group respectively through oral administration.The treatment course lasted for 12 weeks.The angina attack,chest tightness and the dosage of nitroglycerin were recorded daily.The level s of adiponectin（APN） and malondialdehyde（MDA） were detected before and after the treatment.Results Comparing in group,the angina attack and the dosage of nitroglycerin reduced significant ly in both groups after the treatment（P〈0.01）,but the difference between group s was not statistically significant（P〉0.05）.After treatment,the level of APN increased and the level of MDA decreased significantly in the observation group,while the increase of APN and the decrease of MDA in the control group was not significant（P〉0.05）.The levels of triglycerides（TG）,total cholesterol（TC） and low-density lipoprotein cholesterol（LDL-C） were decreased significantly in the observation group after the treatment.There was significant difference in TG and high-density lipoprotein cholesterol（HDL-C） between groups after treatment（P〈0.01）.The differences between groups in TG and high-density lipoprotein cholesterol（H DL-C） were statistically significant（P〈0.01）.Conclusion Jiangzhi Tongluo Soft Gelatin Capsule is effective for angina as combined with the conventional therap y,which maybe relevant to inhibitting the inflammatory reaction and oxidative s tress.
出处
《中医杂志》
CSCD
北大核心
2012年第10期860-863,共4页
Journal of Traditional Chinese Medicine
关键词
降脂通络软胶囊
冠心病
心绞痛
脂联素
丙二醛
Zhikeping Jiangzhi Tongluo Soft Gelatin Capsule（sof t gelatin capsule f or lowering lipid and freeing the network vessels）
coronary heart disease
angi na pectoris
adiponectin
malondialdehyde
