摘要
目的用荟萃分析方法对已发表的雷美替胺治疗慢性失眠疗效进行定量分析。方法收集1966-2011年发表的雷美替胺治疗慢性失眠疗效的所有随机对照研究,对符合条件的研究结果进行荟萃分析,计算雷美替胺相对于安慰剂对慢性失眠患者的睡眠参数。结果符合纳入标准的共有7篇,总样本量3186例。主、客观入睡时间,雷美替胺组比安慰剂组分别减少5.37分(P<0.00001)和10.12分(P<0.00001),主、客观总睡眠时间分别增加4.22分(P=0.04)和6.22分(P=0.03)。结论雷美替胺是治疗慢性失眠有效的药物。
Objective To evaluate the efficacy of remaheon in chronic insomnia based on Meta - analysis. Methods Studies using random- ized, double - blind, placebo - controlled, parallel or crossover designs with remalteon in adults with chronic insomnia that were published between 1966 and 2011 in English were selected for review. The weighted mean difference （WMD） of self - report and polysomnographic measures of sleep - onset latency, total sleep time between remaheon and placebo were calculated. Results Total 7 studies including 3186 cases were analyzed. Rameheon significantly reduced self - report （ WMD = - 5.37 min, P 〈0. 00001 ） and polysomnographic （ WMD = - 10. 12 min, P 〈 0. 00001 ） sleep - onset latency, and increased self - report （ WMD = 4. 22 min, P = 0. 04 ） and polysomnographic （ WMD = 6. 22 min, P = 0. 03） total sleep time compared to placebo. Conclusion The abovementioned results support the effectiveness of remalteon for the treatment of chronic insomnia.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2012年第5期385-387,共3页
The Chinese Journal of Clinical Pharmacology
关键词
慢性失眠
雷美替胺
荟萃分析
chronic insomnia
remalteon
Meta - analysis
