摘要
目的探讨抗凋亡蛋白Survivin在胃癌组织中的表达及意义。方法应用免疫组织化学方法检测54例胃癌及27例癌旁组织和10例正常胃粘膜组织Survivin蛋白表达,并结合临床指标、预后进行分析。结果癌旁组织与癌组织中Survivin表达阳性率分别为14.8%和38.7%,正常胃粘膜为0,组间阳性表达率差异有显著性(P<0.05)。Survivin表达与患者性别、年龄、淋巴结转移、临床分期均无关(P>0.05),而与肿瘤分化程度及生存预后有关,低分化组较高分化组Survivin表达明显增加(P<0.05),高表达组3年生存率明显低于低表达组(P<0.05)。结论胃癌中Survivin高表达,其表达与肿瘤恶性程度及预后相关,提示Survivin在胃癌发生、发展过程中有重要作用,并可作为判断胃癌预后的一个指标。
Objective To explore the expression of survivin gene in gastric cancerous tissue and clinical significance.Methods All the samples were obtained from patients with gastric cancer who underwent surgery in China-Japan union Hospital from January 1998 to May 2003.Immunohistochemistry was used to detect survivin expression in 54 resected gastric cancerous tissue,27 vicinity of the gastric cancerous tissue and 10 normal gastric tissue.The relationship between survivin expression with clinical index and.prognosis were analyzed.Results Survivin expression rate in the resected gastric cancerous tissue and in the vicinity of the gastric cancerous tissue were 14.8% and 38.7%,respectively.There is no survivin expression in normal gastric tissue.The difference of survivin expression among three groups were significant（P〈0.05）.No statistical difference was observed in the survivin expression in sexuality,ages,lymph node metastasis and clinical TNM stages.But survivin expression is relevant with differentiation and prognosis of gastric cancer.Higher survivin expression in poorly differentiated group than in well-differentiated group were observed（P〈0.05）.Prognosis of lower survivin expression group is better than prognosis of higher survivin expression group.（P〈0.05）.Conclusion Survivin is highly expressed in gastric cancerous tissue.Survivin expression is closely related with degree of malignacy and prognosis.This study suggest that survivin play a great role in the carcinogenesis,growth of gastric cancer and it be used as an index in evaluation of prognosis.
出处
《中国实验诊断学》
2012年第5期844-846,共3页
Chinese Journal of Laboratory Diagnosis
基金
吉林省自然科学基金项目(项目编号201215069)
