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孕妇外周血基质金属蛋白酶-9、白介素-6水平联合B超测定宫颈长度预测早产的研究 被引量:1

Evaluation of plasma matrix metalloproteinase-9 and Interleukin-6 combined with cervical length in the prediction of premature delivery
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摘要 目的探讨孕妇外周血基质金属蛋白酶一9(MMP-9)、白介素-6(IL-6)及宫颈长度对早产预测的应用价值。方法选择本院正常妊娠组孕妇23例,先兆早产孕妇39例,按是否继续妊娠为2个亚组,早产分娩组18例,继续妊娠组21例,分别采集各组静脉血,分离血浆应用ELISA方法测定MMP-9及IL-6水平,同时采用B超测定宫颈长度,预测孕妇早产发生情况。结果(1)早产分娩组孕妇MMP-9及IL-6水平显著高于正常妊娠组及继续妊娠组[(47.24±6.41)ng/ml,(523.24±62.35)pg/mlvs(20.39±7.23)ng/ml,(219.29±80.23)pg/ml,(32.18±5.16)ng/ml,(406.18.4-71.52)pg/ml],其差异均有统计学意义(P〈0.01),继续妊娠组血浆MMP-9及IL-6水平显著高于正常妊娠组[(32.18±5.16)ng/ml,(406.18±71.52)pg/mlvs(20.39±7.32)ng/ml,(219.29±80.23)pg/ml],其差异均有统计学意义(P〈0.01);(2)早产分娩组宫颈长度显著低于正常妊娠组及继续妊娠组[(15.62±2.31)mmVS(31.05±1.48)mm,(26.14±3.12)mm,P〈0.01],继续妊娠组孕妇宫颈长度稍低于正常妊娠组[(26.14±3.12)mmVS(31.05±1.48)mm],但差异无统计学意义(P〉0.05)。结论孕妇外周血中MMP-9、IL-6水平高低及宫颈长度可作为早产发生的预测指标。 Objective To investigate predictive value of matrix metalloproteinase-9 (MMP-9) and Interleukin-6 (IL-6) combined with cervical length in premature delivery. Methods Plasma samples of 62 pregnant women were detected in this study. Samples were divided into three groups based on pregnancy outcomes. MMP-9 and IL-6 values were determined by ELISA. Cervical length was measured by transvagi- nal sonography. Results The level of MMP-9 of the pregnant women in the premature delivery group was significantly higher than that of continuous pregnant group and that of normal pregnant women [ (47. 24 ± 6.41 ) ng/ml, (523.24 ± 62. 35 ) pg/ml vs (20. 39 ± 7.23 ) ng/ml, (219. 29 ± 80. 23 ) pg/ml, ( 32. 18 ± 5. 16)ng/ml, (406. 18 ±71.52)pg/ml, P 〈0. 01 ]. The level of MMP-9 and IL-6 of the pregnant women in the continuous pregnant group was significantly higher than that of normal pregnant women [ ( 32. 18 ± 5.16) ng/ml, (406. 18 ± 71.52) pg/ml vs (20. 39 ± 7. 32)ng/ml, (219. 29 ±80. 23 ) pg/ml, P 〈 0. 01 ]. Cervical length of the pregnant women in the premature delivery group was significantly shorter than that of normal pregnant women and that of continuous pregnant group [ ( 15.62 ± 2. 31 ) mm vs ( 31.05 ± 1.48 ) mm, (26. 14±3.12)mm, P 〈0. 01 ]. Conclusions Detection of level of MMP-9 and IL-6 combined with measurement of cervical length can be used as predicting index of premature delivery.
作者 张霞 谭晓群
出处 《中国医师杂志》 CAS 2012年第4期477-479,482,共4页 Journal of Chinese Physician
关键词 基质金属蛋白酶9/血液 白细胞介素6/血液 宫颈长度测量 早产/代谢/诊断 Matrix met alloproteinase 9/blood Interleukin-6/blood Cervical length measurement Premature birth,/metabolism/diagnosis
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