摘要
目的:探讨武汉大学中南医院20年来收治的溃疡性结肠炎(UC)患者临床及内镜特征的变化趋势。方法:回顾性分析武汉大学中南医院1991年1月1日至2000年12月31日和2001年1月1日至2010年12月31日两个时间阶段各10年中,连续收治的有完整记录的UC患者资料,对这两个时间段的UC患者的病例数、性别、年龄、临床症状、病情程度、病变范围、疾病类型、病程、内镜表现、肠外表现及并发症等相关临床特点进行统计和比较分析。结果:共有404例UC患者,第一时间段有104例,第二时间段有300例,第一时间段与第二时间段性别比分别为2.06∶1和1.04∶1,两组性别比有显著性差异(P<0.01);两组平均发病年龄分别为45.1岁和41.9岁,两组比较差异有显著性意义(P<0.05);与第一时间段比较,第二时间段血便、黏液便、消瘦较多见,而腹痛、里急后重较少见(P<0.05);中度UC多见(P<0.05);病变范围以直肠及全结肠较多见,左半结肠少见(P<0.01);肠外表现发生率较低(P<0.05)。肠镜下弥漫性、连续性病变、充血水肿、糜烂、浅表溃疡、脓性分泌均较多见(P<0.01)。结论:近20年来我院UC患病率显著增加,性别构成差别趋向缩小,发病年龄趋向年轻化,发病部位有向全结肠蔓延的趋势,中度UC逐渐增多,轻度UC逐渐减少,临床症状与肠镜下表现均提示UC的病变严重程度趋向加重,而肠外表现的发生率有所下降。
Objective： To investigate the changes of clinical and colonscopes characteristics of ulcerative colitis（UC） in a hospital in Wuhan city,central China in the recent 20 years.Methods： The clinical and colonscope＇s characteristics of the patients with ulcerative colitis were retrospectively analyzed in Zhongnan Hospital of Wuhan University from Jan 1,1991 to Dec 31,2010.All patients were divided into two groups according to different time phases.Results： Of all the 404 consecutive recorded patients,104 patients with a mean age of 45.1 years were from year 1991 to 2000（group A）,and the other 300 patients with a mean age of 41.9 were from year 2001 to 2010（group B）.The age of the patients in group B was younger than that in group A at the time of diagnosis（P0.01）.The difference of sex ratio between the two groups was significant（P0.01）.Compared with that respectivley in the group A,blood stool,mucus and pus stool,weight loss in UC were more common in the group B（P0.05）,whereas abdominal pain and tenesmus were less common（P0.05）;extensive colitis and proctitis were more common,and left-sided colitis was less common（P0.01）;moderate UC was more common in the group B（P0.05）.However,the incidence of extraintestinal manifestation was lower in the group B（P0.05）,the diffuse lesions,continuous distribution congestion and edema,erosion,superficial ulceration and purulent secretion of intestinal mucosa were more common in the group B（P0.01）.Conclusion： During the recent 20 years,the prevalence of UC in this hospital increases significantly,gender difference tends to decrease,the age of onset is getting younger,UC tends to spread to the extensive colon,moderate UC increases and mild UC decreases gradually,the UC clinical and colonoscopy manifestations are more severe,and the incidence of extra-intestinal manifestations decreases.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2012年第3期434-437,共4页
Medical Journal of Wuhan University
关键词
溃疡性结肠炎
临床特征
比较研究
内镜特征
Ulcerative Colitis
Clinical Characteristics
Comparative Research
Colonoscope Characteristics
