摘要
目的了解胱氨酸蛋白酶抑制剂C(CysC)的检测在诊断慢性肾功能衰竭中的临床意义。方法对本院住院和门诊的慢性肾功能衰竭患者进行血清CysC、尿素氮(BUN)、血肌酐(Cr)测定,同时对健康者进行相关检测,并比较分析检测结果。结果健康对照组与慢性肾功能衰竭患者CysC差异有统计学意义(P<0.01);在肾贮备能力下降期和氮质血症期患者血清中CysC异常值检出率分别为46%和75%,BUN分别为12%和46%,Cr分别为15%和43%,差异有统计学意义(P<0.01);在肾衰竭期和尿毒症期患者血清中CysC异常值检出率与BUN、Cr基本相同,差异无统计学意义(P>0.01)。结论血清中CysC可作为慢性肾功能衰竭的一个较好的早期检测指标,特别是在肾储备能力下降期和氮质血症期的诊断中灵敏度、特异性较BUN、Cr高,但在肾衰竭期和尿毒症期,CysC检测并不比BUN、Cr优越。
Objective To investigate the clinical significance of cystatin C（CysC） in diagnosis of chronic renal failure. Methods The levels of serum CysC,blood urea nitrogen（BUN）, creatinine（Cr） from patients with chronic renal failure and from the healthy subjects were analyzed. Results The difference in the concentration of CysC in the healthy control group and patients with chronic renal failure was significantly different（P0.01）. For the patients with decreasing renal reserve capacity and nephropathy azotemia, the outlier detection rates was 46% and 75% for CysC,12% and 46% for BUN, and 15% and 43% for Cr, respectively. The difference was significance（P0.01）. The outlier detection rate of CysC in patients with chronic renal failure and uraemic period was the same as BUN and Cr; and the difference was not of significant. Conclusions The concentration of serum CysC can be used for early detection and diagnosis of chronic renal failure. The sensitivity and specificity of the tests in renal reserve capacity decreased period and azotemia period was higher than BUN and Cr. CysC may not be better than BUN and Cr for diagnosis in patients with kidney failure stage and uremia period.
出处
《热带医学杂志》
CAS
2012年第4期461-463,共3页
Journal of Tropical Medicine
