摘要
以苯并异噻唑-3(2H)-酮(BIT)及氯乙醇为原料微波法合成了2-羟乙基苯并[d]异噻唑-3(2H)酮。考察了氢氧化钠量,氯乙醇用量,反应时间,反应温度对反应的影响,经正交实验设计得到了最佳反应条件,最佳反应条件下收率为83.3%。结果表明,与传统工艺相比,微波技术合成2-羟乙基苯并[d]异噻唑-3(2H)-酮的方法具有操作方便、收率高等特点,具有一定的应用价值。
Microwave irradiation was used to the synthesis of 2-hydroethyl-benzo [d] isothiazole-3 （2H）-one from the starting materi- al benzo [d] isothiazole-3 （2H）-one and 2-chloroethanol. The influence of the tool ratio of sodium hydroxide and 2-chloroethanol was studied, as well as the time and the temperature of the reaction. The optimum reaction condition was determined through orthogonal experiment. Under the optinum reaction condition ,the refined yield reached 83.3%. The result showed that the microwave synthesis of 2-hydroethyl-benzo[ d] isothiazole-3 （2H）-one was more convenient than traditional ones, with faster reaction speed and higher yield. Thus, it could be a promissing way for utilization.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2012年第5期778-782,共5页
Chemical Research and Application
基金
国家自然基金项目(20962007)资助
