摘要
目的研究Livin蛋白在原发性支气管肺癌中的表达及其临床意义。方法应用免疫组织化学SP法检测52例手术切除的肺癌石蜡标本及7例正常肺组织中的Livin蛋白表达情况。结果 (1)肺癌患者肺组织中Livin蛋白表达的阳性率为48.1%,正常肺组织呈阴性表达;(2)男性肺癌患者Livin蛋白的表达阳性率为59.26%,女性为36.00%,两者相比差异有统计学意义(P<0.05);(3)支气管肺癌的病理类型、组织分化程度、临床分期对Livin蛋白表达阳性率的影响无统计学差异(P>0.05)。而有淋巴结转移的肺癌患者Livin蛋白表达阳性率(57.89%)高于无淋巴结转移的患者(36.37%,P<0.05);(4)吸烟指数≥400的肺癌患者Livin蛋白表达阳性率53.57%,吸烟指数<400的患者为33.33%,两者相比差异有统计学意义(P<0.05)。结论 Livin蛋白的高表达在支气管肺癌的发生发展过程中起重要作用,Livin蛋白的表达与肺癌的病理类型、组织的分化程度、临床分期无关,与有无淋巴结转移、吸烟指数密切相关。
Objective To study the protein expression level and clinical significance of Livin gene in primary lung cancer. Methods The protein expression of Livin gene in paraffin specimens of 52 cases of lung cancer and 7 specimens of normal lung tissues were detected by SP immunohistochemistry. Results （ 1 ） The positive rate of Livin protein expression in lung cancer specimens was 48.1%, but the normal lung tissues were negative staining. （2） The positive rate of Livin protein expression in male lung cancer specimens （59. 26% ）was higher than that in female lung tissues（36. 00% ,P 〈 0. 05 ）. （3）Livin protein expression in lung cancer had no obvious relationship with the pathologic type, grade, and clinical stage. The positive rate of Livin protein expression in specimens with lymph node metastasis（57.89% ）was higher than in tissues without lymph node metastasis（36. 37%, P 〈 0.05 ）. （4） The positive rate of expression of Livin protein in patients whose smoking index≥400 and in patients that 〈400 was 53.57% and 33.33% , respectively, the differences were significant （ P 〈 0. 05 ）. Conclusions Livin protein expression in lung cancer has no obvious relationship with the pathologic type, grade, and clinical stage. It is closely related to lymph node metastasis and smoking index.
出处
《中华临床医师杂志（电子版）》
CAS
2012年第9期82-84,共3页
Chinese Journal of Clinicians(Electronic Edition)
