摘要
目的观察华蟾素注射液经左锁骨下动脉植入药盒持续泵注联合中药治疗胃肠道肿瘤肝转移的临床疗效。方法将50例胃肠道肿瘤肝转移患者随机分为中药组和对照组,各25例。对照组经左锁骨下动脉植入药盒注入5-FU、DDP;中药组经左锁骨下动脉植入药盒注入华蟾素注射液,同时结合内服中药;两组均以4周为1个治疗周期,共治疗6个周期,观察患者临床症状、生活质量、不良反应以及细胞免疫功能变化情况,并随访中位生存期及1年生存率。结果中药组、对照组总有效率分别为68.0%、40.0%,组间临床疗效比较,差异有统计学意义(P<0.05);治疗组治疗前后组内比较,生活质量评分差异有统计学意义(P<0.05),对照组差异无统计学意义(P>0.05);组间治疗后比较,差异有统计学意义(P<0.05)。治疗组治疗前后组内比较,CD3、CD4、CD8、CD4/CD8差异有统计学意义(P<0.05),对照组CD3、CD4/CD8差异有统计学意义(P<0.05);组间治疗后比较,CD4/CD8差异有统计学意义(P<0.05);组间毒副反应情况比较,差异有统计学意义(P<0.05)。中药组1年生存率为80.0%,中位生存期为18.38个月;对照组1年生存率为76.0%,中位生存期为17.63个月;组间比较,差异无统计学意义(P>0.05)。结论华蟾素注射液经药盒持续灌注联合中药可改胃肠肿瘤肝转移患者的临床症状,提高生存质量和细胞免疫功能,可有效用于胃肠道肿瘤肝转移的治疗。
Objective To observe the clinical efficacy of Chinese medicine plus Cinobufotalin injection through a port-caheter drug delivery system（PCDDS） for liver metastasis from gastrointestinal malignant tumors.Methods Fifty subjects were randomized into two groups： control group in which 25 cases were treated with 5-FU and DDP by port-catheter drug delivery system through left subclavian artery;treatment group in which 25 cases were treated with Cinobufotalin injection and Chinese medicine,for 6 courses and 4 weeks as one course.The clinical symptoms,QOL,adverse effect and cellular immune function were observed,and the median survival time and survival rate in one year were surveyed.Results The effective rate was 68.0% in treatment group and 40.0% in control group;there was a significant difference in clinical efficacy between the 2 groups（P0.05）;in treatment group,the significant difference was found in QOL between before and after treatment（P0.05）,no significant difference was found in control group（P0.05）;after treatment,there was a significant difference between the 2 groups（P0.05）.In treatment group,there were significant differences in CD3,CD4,CD8 and CD4/CD8 between before and after treatment（P0.05）;in control group,there were significant differences in CD3 and CD4/CD8 between before and after treatment（P0.05）;there was a significant difference in CD4/CD8,adverse reaction between the 2 groups after treatment（P0.05）;the survival rates of one year were 80.0% and 76.0% in treatment group and control group respectively;the median survival time was 18.375 months and 17.625 months in treatment group and control group respectively,without significant difference between the 2 groups（P0.05）.Conclusion Combined Chinese medicine and Cinobufotalin injection can relieve the symptoms and improve the QOL and cellular immune function,and works well on liver metastasis from gastrointestinal malignant tumors.
出处
《上海中医药杂志》
2012年第5期39-41,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
上海中医药大学附属普陀医院科研基金项目(2009L25)
关键词
胃肠肿瘤
肝转移
中医药疗法
华蟾素
gastrointestinal malignant tumor
liver metastasis
Chinese medicine
Cinobufotalin
