摘要
目的:观察复方血栓通胶囊对糖尿病白内障患者超声乳化吸除术后发生黄斑水肿的预防作用。方法:采用随机对照临床研究方法。收集180例180眼糖尿病老年性白内障患者,排除术前有眼内手术史、葡萄膜炎、玻璃体视网膜疾病、青光眼,角膜白斑,术后出现严重角膜水肿、葡萄膜炎、前房出血、继发性青光眼等并发症的患者,随机分为研究组和对照组。研究组(90例)术后立即口服复方血栓通胶囊1.5g,连续服用2wk;对照组(90例)患者不使用复方血栓通胶囊,观察两组术后1,7d;1,3,6,12mo的视力及黄斑水肿发生情况。结果:研究组术后1,7d;1,3,6,12mo的视力均值明显高于对照组(P<0.01);研究组术后12例发生黄斑囊样水肿,对照组术后26例发生黄斑囊样水肿,研究组发生黄斑水肿几率(13.3%)明显低于对照组(28.9%,P<0.01)。结论:复方血栓通胶囊能改善糖尿病患者白内障超声乳化吸除术后视神经视网膜缺血和缺氧状态,减少黄斑中心凹周围毛细血管渗漏,预防黄斑水肿的发生。
AIM：To study the preventive effect of Fufang Xueshuantong capsule on macular edema after phacoemulsification in diabetic cataract patients. METHODS： Using single-center randomized controlled clinical research,180 cases （180 eyes）of diabetic cataract patients were collected. Exclusion criteria included a history of previous intraocular surgery, vitreous loss during cataract surgery, uveitis, vitreoretinal pathology, glaucoma, cornea spot, and postoperative severe corneal edema, uveitis, anterior chamber bleeding, secondary glaucoma.They were divided into research group and control group. The research group patients （90 cases）had Fufang Xueshuantong capsule 1.5g tid immediately after surgery, continuously used for 2 weeks; the control group patients （90 cases） did not. The visual acuity of two groups and the incidence of macular edema were observed 1 day, 7 days, 1 month, 3, 6 and 12 months postoperatively. RESULTS：One day,7 days, 1 month, 3,6,12 months postoperatively, the mean vision of the research group was markedly higher than that in control group （P0.01）. In the research group, 12 cases had macular edema. 26 cases had macular edema in the control group. The incidence of macular edema in research group was markedly lower than that in control group（P0.01）. CONCLUSION：After uneventful phacoemulsification in diabetic cataract patients,Fufang Xueshuantong capsule can improve the ischemia and hypoxia state of optic nerve and retina,reduce macular foveal capillary leakage and prevent the occurrence of macular edema.
出处
《国际眼科杂志》
CAS
2012年第6期1163-1165,共3页
International Eye Science
