摘要
目的对急性脑梗死病人进行血浆tPA、PAI-1、uPA及uPAR水平的联合检测,探讨其治疗观察及预后判定的临床价值。方法急性脑梗死病人(36例)及对照组在治疗前和治疗后分别进行血浆tPA、PAI-1、uPA及uPAR的联合检测(ELISA法)。结果 36例脑梗死病人治疗前与对照组相比tPA、PAI-1、uPA和uPAR水平均有明显增高(均P<0.01);治疗后与治疗前比较tPA又有明显升高(P<0.05),而PAI-1,uPA and uPAR则在治疗后明显降低(P<0.05,P<0.01),PAI-1及uPAR降至接近对照组水平(P>0.05)。结论血浆tPA、PAI-1、uPA和uPAR水平的变化与脑梗死病人的治疗状况密切相关,联合检测有利于对急性脑梗死的治疗观察和预后判定。
Objective To study the clinical value of combining detecting the levels of tPA, PAl - 1 ,uPA and uPAR in plasma of patients with acute cerebral infarction for treatment observation and progn - assessment. Methods PAl - 1 ,uPA and uPAR were detected respectively by ELASA in 36 cases of the patients with acute cerebral infarction in pre - therapy, pro - treatment and control groups. Results Compared to the control group, the levels of tPA, PAl - 1 ,uPA and uPAR of pre - therapy group were obviously high （ all P 〈 0. 01 ）. Compared to the pre - therapy group, the level of pro - treatment tPA was obviously high （P 〈 0.05 ） , the levels of PAl - 1, uPA and uPAR were obviously low（ P 〈 0.05 ,P 〈 0.01 ） , and the levels of PAl -1 and uPAR were decreased to the levels of control group. Conclusion The plasma levels of tPA, PAl - 1 ,uPA and uPAR are closely interrelated with the treatment state in the patients with acute cerebral infarction. Combining detecting the levels of tPA,PA1 - 1, uPA and uPAR is benifit for the evaluation of the progn - assessment and treatment state in the patients with acute cerebral infarction.
出处
《医学研究杂志》
2012年第5期156-158,共3页
Journal of Medical Research
