摘要
目的探讨麻疹减毒活疫苗治疗上皮型单纯疱疹病毒性角膜炎(HSK)的临床效果。方法选取在钟祥市人民医院眼科门诊确诊的60例(60眼)上皮型HSK患者,随机分为对照组和试验组,每组30例。对照组给予更昔洛韦滴眼液滴眼,每日8次;试验组球结膜下注射麻疹减毒活疫苗,隔日1次,每次0.5 mL,联合更昔洛韦滴眼液滴眼,每日8次,治疗3周。观察治疗后1、2、3周的治疗效果,随访2 a,观察其复发率。结果对照组在治疗后第1、2、3周的症状与体征评分分别为2.533±0.507、2.133±0.730、1.433±0.728,试验组分别为2.200±0.252、1.800±0.761、1.067±0.254,2组各相应时间点评分比较差异均有统计学意义(P<0.05);治疗后第1、2、3周2组间各时间对应点角膜知觉情况比较差异有统计学意义(P<0.05)。对照组在治疗后第2、3周眼部炎症反应的治愈率分别为13.33%(4/30)、26.67%(8/30),试验组分别为33.33%(10/30)、66.67%(20/30),2组比较差异有统计学意义(P<0.05)。随访2 a,对照组复发率为26.67%,试验组为6.67%,2组比较差异有统计学意义(P<0.05))。2组患者均未出现明显不良反应。结论应用更昔洛韦滴眼液联合麻疹减毒活疫苗球结膜下注射治疗上皮型HSK具有治愈率高、不良反应少、复发率低等优点。
Objective To investigate clinical effect of epithelial herpes simplex keratitis（HSK） treated by live attenuated measles vaccine. Methods Sixty epithelial HSK patients diagnosed at Zhongxiang people′s hospital were enrolled.All the patients were divided into control group and experimental group randomly,30 patients in each group.The control group patients were treated by ganciclovir eye drops,8 times per day,while experimental group patients were treated by ganciclovir eye drops（8 times per day） as well as sub-conjunctival injection of live attenuated measles vaccine（0.5 mL per time,every other day）.All patients were treated for 3 weeks,and the curative effect after treating for 1 week,2 weeks and 3 weeks was observed.All patients were followed up for 2 years to observe the relapse rate. Results The scores for symptoms and signs in control group patients in the first,second and third week after treatment were 2.533±0.507,2.133±0.730,1.433±0.728 individually,which were 2.200±0.252,1.800±0.761,1.067±0.254 individually in experimental group patients,the differences were significant（P0.05）.After treatment for 1 week,2 weeks and 3 weeks,there were statistically significant differences in corresponding time in the perception of cornea between two groups（P0.05）.The cured rate in control group after 2 weeks and 3 weeks-treatment were 13.33%（4/30）,26.67%（8/30）,which were 33.33%（10/30）,66.67%（20/30） in experimental group,the differences between the two groups were significant（P0.05）.The relapsing rate in control group and experimental group was 26.67% and 6.67% respectively after following up for two years,and a significant difference was also observed（P0.05）.There was no obviously adverse reaction occurred in the two group patients. Conclusion The treatment that ganciclovir eye drops combining with sub-conjunctival injection of live attenuated measles vaccine on epithelial HSK has the advantage of higher recovery rate,less side effect and lower relapsing rate.
出处
《新乡医学院学报》
CAS
2012年第6期454-456,共3页
Journal of Xinxiang Medical University
