摘要
背景:缺血性脑血管病严重危害人类的健康,但现有的治疗措施对许多患者还未取得理想的效果,如何促进脑缺血患者受损神经功能的修复仍是目前研究的重点。目的:利用CNKI数据库文献检索,对干细胞移植在缺血性脑卒中治疗中的应用的文献资料趋势进行多层次探讨分析。设计:文献计量学分析。资料提取:以电子检索方式对CNKI数据库2006-01/2011-12有关干细胞移植在缺血性脑卒中治疗中的应用的文献进行分析,检索词"干细胞(stem cells);移植(transplantation);脑缺血(cerebral ischemia)",对检索的相关文献运用数据库的分析功能结合Excel软件绘制图表的功能进行分析,通过文字和图表的形式将统计和计量数据分析来描述其分布特征。入选标准:纳入标准:与干细胞移植在缺血性脑卒中治疗中的应用相关的基础和临床研究论文。排除标准:①与文章目的无关的文献。②重复研究的文献。③刊社信息。④未发表的文献。⑤需电话追踪和手工检索逐一分析的文献。⑥年鉴。主要数据判定指标:文献出版时间、文献数量、学科类别、研究机构、来源期刊、文献被引频次、文献下载频次、作者分布、基金资助情况和主要关键词进行相关分析。并对不同来源的干细胞移植在缺血性脑卒中治疗中应用的研究进行对比分析。结果:在CNKI数据库学术期刊收录2006/2011的文献中,共检索到231篇与干细胞移植在缺血性脑卒中治疗中的应用相关的文献。文献数量产出呈现波动状态,其中2007年和2009年文献产出数量最多;骨髓间充质干细胞,神经干细胞,羊膜间充质细胞是目前在缺血性脑卒中治疗中的应用中研究最多的细胞种类。《中国组织工程研究与临床康复》杂志发表文献量为36篇,占全部文献的15.6%。44篇干细胞移植在缺血性脑卒中治疗中应用的相关文献获得国家自然科学基金的资助。脑缺血,神经干细胞及骨髓间充质干细胞是发表文章使用最多的关键词。结论:CNKI数据库学术期刊关于干细胞移植在缺血性脑卒中治疗中应用的文献分析,可为中国从事脑血管病治疗的基础研究和临床实施的医务工作者进一步确定科研思路提供有价值的参考。
BACKGROUND： Ischemic cerebrovascular disease is a serious hazard to human health, which can not be treated effectively at present. How to promote recovery of impaired neural functions for patients with ischemic cerebrovascular disease is the study focus. OBJECTIVE： To explore the literature data trends in the study of stem cell transplantation for treating ischemic stroke by using search and the depth of analysis capabilities of CNKI database. DESIGN： Bibliometric data analysis DATA RETRIEVAL： A search of related literature of stem cell transplantation for treating ischemic stroke was performed in CNKI database using the key words of ＂stem cells＂ ＂transplantation＂ and ＂cerebral ischemia＂ during 2006-01 to 2011-12. The retrieval results were analyzed, and the trends were described in words and graphics. SELECTION CRITERIA： Inclusive criteria： Basic research and clinical application of stem cell transplantation for treating ischemic stroke. Exclusive criteria： （1） Literature has nothing to do with the purpose of this review. （2） Duplicated research literature. （3） Journal＇s own information. （4） Unpublished papers. （5） The article needs to be retrieved by phone or manual searches. （6） Year book. MAIN OUTCOME MEASUREMENTS： The literatures were analyzed by published year, literature number, subject category, research institutions, source journals, literature citations, literature download frequency, associated literature, distribution of the author, distribution of the funding and major keywords. Additionally, the stem cells from different sources were compared in treating ischemic stroke. RESULTS： A total of 231 research literatures related to stem cell transplantation for treating ischemic stroke were retrieved in CNKI during 2006 to 2011. The number of papers was fluctuated in the past 6 years. Most literatures were published in 2007 and 2009. Bone marrow mesenchymal stem cells, neural stem cells, and amniotic mesenchymal stem cells are the major cells in the study. Journal of Clinical Rehabilitative Tissue Engineering Research published 36 literatures, accounting for 15.6% of all literatures. A total of 44 articles were supported by the National Natural Science Foundation of China. The frequently used key words in stem cell transplantation for treating ischemic stroke are ＂cerebral ischemia＂, ＂neural stem cells＂ and ＂bone marrow mesenchymal stem cells＂. CONCLUSION： The bibliometric data analysis on stem cell transplantation for treating ischemic stroke can provide valuable reference for Chinese medical physicians in ischemic stroke field.
出处
《中国组织工程研究》
CAS
CSCD
2012年第19期3576-3583,共8页
Chinese Journal of Tissue Engineering Research
