摘要
目的分析医院严重药品不良反应(ADR)发生情况,以降低其发生率及危害程度。方法对2004年1月至2011年4月医院自发呈报的药品不良反应,按调查表进行统计分析。结果 1 259例药品不良反应中,严重者154例。154例严重药品不良反应中,64.29%的严重药品不良反应由静脉给药引起;可影响消化、血液、泌尿生殖等全身各个系统;涉及可疑药品12类93种,以抗感染药物最常见(占51.15%),引起严重药品不良反应排名前10位的药品中,抗感染药物高达7种;发生于给药开始即刻至给药282 d后,部分严重药品不良反应可能与不合理用药有关,如单次用量过大、用药总量过大、给药速度过快、联合用药不当等。结论了解药品的主要不良反应,合理使用药品,有针对性地观察监测,有助于降低严重药品不良反应的发生率及危害性。
Objective To investigate the status of serious adverse drug reaction （ADR） in our hospital to reduce its incidence and the extent of injure.Methods ADR cases reports in our hospital from January 2004 to April 2011 were collected and statistically analyzed according to the questionnaires.Results Of collected 1 259 ADR cases,154 cases were serious ADR.Most of them were resulted from intr avenous administration,which accounted for 64.29%.Serious ADR affected digestiv e,circulatory,urinary and reproductive and other systems.The involved suspicious drugs were 93 varieties 12 categories.Anti-infectives were the most common（51.15%）.Among the 154 cases of serious ADR occurred from immediately beginning of drug administration to after 282 d after administration.Partial serious ADR cou ld be related with irrational drug use,such as too large single dose,too lager t otal doses,too fast administration and improper combination drug use.In addition,12 serious ADR cases may be related to irrational drug uses,including overhigh single drug dose,over dose,and so on.Conclusion Understanding the main adverse r eactions of drugs,rational drug use and targeted observation and monitoring are conducive to reduce the occurrence and harmfulness of serious ADR.
出处
《中国药业》
CAS
2012年第9期42-44,共3页
China Pharmaceuticals
关键词
严重
药品不良反应
合理用药
serious
adverse drug reaction
rational drug use
