摘要
建立了高效液相色谱(HPLC)法测定富马酸喹硫平片的有关物质的方法。色谱柱为依利特(ODS 5μm,4.6mm×250mm),以甲醇-水-三乙胺(670∶330∶4)用磷酸调节pH值为6.8为流动相,流速为1.0mL/min,检测波长为289nm。该方法简便、准确、专属性强,可用于富马酸喹硫平片中有关物质的测定。
To establish a high performance liquid chromatographic（HPLC）method for the determination on the related substances in quetiapine fumarate tablets.The chromatographic analysis was performed on Elite（ODS 5 μm,4.6 mm×250 mm）column.The mobile phase was methanol-water-triethylamine（670∶330∶4）which pH value was adjust to 6.8 by phosphoric acid.The flow rate was 1.0 mL·min-1,detection wavelength was 289 nm.The method was simple,accurate,specific,and could be used for the determination on related substances in quetiapine fumarate tablets.
出处
《河北化工》
2012年第5期30-32,共3页
Hebei Chemical Industry
