摘要
目的 :探索那屈肝素钙治疗脑梗死的疗效及治疗前后凝血因子I(Fg) ,凝血因子Ⅱ (昔名凝血酶原 )时间 (PT) ,血小板粘附率 (PAR) ,总胆固醇(TC)及三酰甘油 (TG)的变化。方法 :4 0例脑梗死病人 [男性 2 8例 ,女性 12例 ,年龄 (6 4±s9)a],除常规治疗 (甘露醇、尼莫地平等 )外 ,给予那屈肝素钙0 .4mL(4 10 0IUAXa)sc ,bid× 10d ,治疗前后测定Fg ,PT ,PAR ,TC及TG并以 38例脑梗死病人用常规治疗为对照组。结果 :治疗组显效率 72 % ,2组疗效差异有显著意义 (P <0 .0 5)。治疗前后Fg降低(0 .7± 2 .0 ) g·L- 1,PT延长 (3± 9)s ,PAR降低(3.9± 2 .0 ) % ,差异有非常显著意义 (P <0 .0 1或P<0 .0 5) ,血脂改变无显著意义 (P >0 .0 5)。结论 :那屈肝素钙具有抗凝溶栓作用 ,对急性脑梗死有效 ,且无增加再出血的危险。
AIM: To understand the therapeutic effects of nadroparin calcium and the variations of fibrinogen(Fg),prothrombin time(PT),platelet adhesion rate(PAR),TC and TG before and after treatment. METHODS: Patients( n =40) with acute cerebral infarction [M 28, F 12, age (64± s 9) a] recieved 0.4 mL of nadroparin calcium(4100 IUAXa),bid,sc for 10 d besides conventional therapy (mannitol, nimodipine, etc). The Fg,PT,PAR, TC and TG of the patients before and after the treatment were determined and compared with those of the control group of 38 patients of the same disease. RESULTS: One course of treatment with nadroparin calcium showed a statistically significant effective rate of 72 % ( P <0.05). The Fg was lowered (0.7± 2.0) g·L -1 ; the PT was lengthened(3±9)s;the PAR was reduced (3.9±2.0)% very significanly( P < 0.01 );the blood lipids did not changed( P >0.05) significantly. CONCLUSION: Nadroparin calcium is effective in combating coagulation and treating acute cerebral infarction with no hazard of reoccurrence of hemorrhage.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2000年第3期184-186,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
急性脑梗死
药物疗法
那屈肝素钙
nadroparin
low molecular weight heparin
cerebral infarction
fibrinogen
prothrombin time
platelet adhesiveness
cholesterol
triglycerides
