摘要
目的 探讨肾移植术后发生丙型肝炎的受者合理的免疫抑制方案。方法 将 2 5例丙型肝炎病毒RNA(HCVRNA)阳性的患者分为 3组 ,分别给予硫唑嘌呤 (Aza) +环孢素A(CsA) +泼尼松 (Pred) (Aza组 )、霉酚酸酯 (MMF) +CsA +Pred(MMF组 )和MMF +Pred ,并以 30例HCVRNA阴性受者为对照。结果 Aza组有 8/12的患者肝功能发生异常 ;MMF组有 2 /8的患者肝功能发生异常 ;MMF +Pred组原有的肝功能异常均好转 ;对照组有 10例患者发生肝功能异常 ,经过调整Aza与CsA的剂量后 ,肝功能均在 1周内全部好转。结论 HCVRNA阳性的患者肾移植术后宜采用MMF +CsA +Pred三联疗法 ;肝功能损害较难控制时 ,使用MMF +Pred可以稳定肝。
Objective To study the use of immunosuppressives for the patients with virus C hepatitis (HCV) after renal transplantation. Methods Twenty five cases of HCV RNA(+) and 30 cases of HCV RNA(-) as control group were analyzed. All patients were divided into the Aza group ( n =12), MMF group ( n =8) and MP (MMF+Pred) group ( n =5). Results Eight cases revealed abnormal liver function in the Aza group and 2 in MMF group. After stopping the use of CsA and Aza, the liver function all revealed good outcome in the MP group . During one week 30 cases of HCV RNA(-) recovered due to the readjustment of the dosage of immunosuppressives (CsA, Aza) in the control group. Conclusions The therapy of MMF+CsA+Pred is necessary for the patients with HCV RNA(+) and the function of the renal and liver can be stabilized by MMF.
出处
《中华器官移植杂志》
CAS
CSCD
2000年第3期151-152,共2页
Chinese Journal of Organ Transplantation
关键词
肾移植
免疫抑制剂
肝功能试验
丙型肝炎
Kidney transplantation
Hepatitis C
Immunosuppressive agents
Liver function tests
