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铜(Ⅱ)-氟喹诺酮类抗生素螯合物与虎红体系的吸收和共振瑞利散射光谱及其分析应用研究 被引量:4

Absorption Spectra and Resonance Rayleigh Scattering Spectra of Cu(Ⅱ)-Fluoroquinolone Chelates with Tetrachlorotetraiodo-fluoresceindisodium Salt System and Their Analytical Applications
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摘要 在pH 4.2~4.8的B-R缓冲介质中,莫西沙星(MXFX)和加替沙星(GTF)等氟喹诺酮类抗生素(FLQs)能与铜(Ⅱ)形成螯合阳离子,进一步与虎红(Tf)阴离子通过静电引力和疏水作用形成FLQs∶Cu(Ⅱ)∶Tf为1∶1∶1的离子缔合物,体系反应导致共振瑞利散射(RRS)显著增强并出现新的RRS光谱。两种药物的反应产物具有相似的光谱特征,最大RRS峰位于373 nm处,并在590 nm处有1个较小的散射峰。在373 nm处一定浓度的抗生素与散射增强(ΔI)成正比,MXFX和GTF的线性范围分别为0.031~7.8 mg/L和0.029~9.0 mg/L。据此建立了测定氟喹诺酮类药物的新方法,方法用于胶囊和人尿液中FLQs的测定并取得满意结果。同时对反应机理及RRS增强原因进行了讨论。 In pH 4.2-4.8 Britton-Robinson(B-R) buffer solution,moxifloxacin(MXFX) and gatifloxacin(GTF) of fluoroquinolone antibiotics(FLQs) could react with Cu(Ⅱ) to form chelate cations,which further bind with tetrachlorotetraiodo-fluoresceindisodium salt(Tf) to form FLQs ∶ Cu(Ⅱ) ∶ Tf(1 ∶ 1 ∶ 1) ion association complexes.The system reactions resulted in the great enhancement of resonance Rayleigh scattering(RRS) and new RRS spectra appeared.The reaction systems of two drugs had similar spectral characteristics,the maximum RRS wavelength situated at 373 nm,and one small scattering peak situated at 590 nm.The intensities of RRS at 373 nm are proportional to the concentrations of antibiotics drugs in the ranges of 0.031-7.8 mg/L for MXFX and 0.029-9.0 mg/L for GTF.Based on this,a new method was developed for the determination of FLQs in capsule and human urine samples.The reaction mechanism and the reasons for RRS enhancement of the system were also investigated.
出处 《分析测试学报》 CAS CSCD 北大核心 2012年第5期546-551,共6页 Journal of Instrumental Analysis
基金 国家自然科学基金(21175015) 教育部春晖计划(Z2009-1-63003)
关键词 莫西沙星 加替沙星 虎红 铜(Ⅱ) 共振瑞利散射 moxifloxacin gatifloxacin tetrachlorotetraiodo-fluoresceindisodium salt Cu(Ⅱ) resonance rayleigh scattering
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