摘要
目的了解头孢菌素引起不良反应(ADRs)并致死的情况,探究其发生规律。方法检索《万方数据》中有关头孢菌素引起ADRs的文献资料(1998-2011年),筛选收集其引起ADRs并致死的案例报告,按年龄、性别、给药途经、原患疾病、发生时间、死亡时间等进行统计分析。结果头孢菌素引起ADRs并致死,在60岁以上老年人中发生较多(37.74%),静脉滴注是主要用药方式(81.13%),全身性损害(71.70%)、过敏性休克(67.92%)是主要表现形式,发生时间较多在用药后10 min内(43.40%),过敏性休克多发生于用药5 min内(55.56%)。结论临床应重视头孢菌素引起的ADRs,尤其是过敏性休克等严重ADRs,鼓励、推广头孢类药物的皮试工作,以确保用药安全。
Objective To investigation the situation and rules of patients death induced by cephalosporins.Methods The patients death induced by cephalosporins from 53 cases,reported in Wanfang date base from 1998 to 2011,were collected and analysed.Results Patients death induced by cephalosporins often occurred in older over 60 years（37.74%）.The main administration routes were through intravenous injection（81.13%）.The clinical symptoms exhibited mainly systemic reactions（71.70%）,and anaphylactic shocks reached to 67.92%.The onset of ADRs was usually within 10 min after administration（43.40%）.The onset of anaphylactic shock was usually within 5 min after administration（55.56%）.Conclusion We should pay more attention to the ADRs of cephalosporins,especially anaphylactic shock.Skin test of cephalosporins is necessary and important.
出处
《广东药学院学报》
CAS
2012年第2期180-182,共3页
Academic Journal of Guangdong College of Pharmacy
关键词
头孢菌素
药物不良反应
文献分析
皮肤试验
cephalosporins
adverse drug reaction
literature analysis
skin test
