摘要
目的探讨阿托伐他汀对高脂血症患者血脂和血清一氧化氮(NO)、血浆内皮素(ET-1)的于影响及停药后各项指标的变化。方法 40例原发性高脂血症患者每日服阿托伐他汀10mg共用8周,第9周停药。分别于服药前、8周末及停药4周末取空腹静脉血,均行血三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、NO、ET-1测定。另选本院同期健康体检者40例作为对照组,要求采血前两周未服用任何药物。结果高脂血症患者血NO水平显著低于对照组,ET-1水平明显高于对照组(均P<0.01)。治疗8周末两组血HDL-C、NO水平显著升高、TG、TC、LDL-C、ET-1水平明显降低(P<0.01)。停药4周末TG、TC、LDL-C、和ET-1均较治疗8周末明显升高,而HDL-C、NO明显下降,差异有统计意义(P<0.01)。结论阿托伐他汀钙能够改善高脂血症患者血脂及内皮功能,且需要长期坚持服用。
Objective To explore the effect of atorvastatin on blood lipid level and vascular endothelial function of patients with hyperlipidemia and the changes of various indexes after discontinuation.Methods 40 cases with hyperlipidemia were treaded with atorvastatin 10mg/d.Blood level of TC,TG,LDL-C,HDL-C,NO and ET-1 were tested before treatment,after treatment 8 weeks and stopping treatment 4 weeks respectively.In addition 40 healthy check-up people,who didn′t take any medicine in 2 weeks before blood sampling were selected as a control group.Results The level of NO was lower and ET-1 content was higher in patients with hyperlipidemia companied with those of the control group（all P0.01）.The serum levels of HDL-C,NO obviously increased and the blood levels of ET-1,TC,TG,LDL-C decreased after treatment 8 weeks（P0.01）.The level of NO,HDL-C were decreased and the blood levels of ET-1,TC,TG,LDL-C increased in patients with hyperlipidemia after stopping treatment 4 week companied with those of after treatment 8 weeks（all P0.01）.Conclusion Atorvastatin can adjust the abnormal blood liquids and improve the endothelial function in patients with hyperlipidemia and need to adhere to the long-term medication.
出处
《实用心脑肺血管病杂志》
2012年第6期972-973,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
