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补肾通络方对糖尿病肾病患者CTGF、MMP的影响 被引量：9

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摘要 目的:观察补肾通络方对糖尿病肾病患者CTGF、MMP的影响。方法:将符合诊断标准的糖尿病肾病(DN)患者随机分为治疗组和对照组,治疗组在西医常规治疗的基础上加用中药补肾通络方进行治疗,对照组单纯用西药治疗,分别于治疗前、后抽血检测CTGF、MMP、糖化血红蛋白、空腹血糖、餐后2 h血糖等指标,收集尿液检测尿微量白蛋白。结果:治疗组患者的血糖、糖化血红蛋白较对照组有所下降,但差异无统计学意义。治疗组患者的CTGF由10.36±1.25下降至7.62±0.89;MMP-9由1014.32±97.35上升至1123.56±99.42,差异具有统计学意义(P<0.01)。结论:补肾通络方可以降低糖尿病肾病患者CTGF,升高其MMP-9,有一定的抗肾小球纤维化作用,值得作进一步的研究。
作者 闵存云 付婷婷 杜玉 王昌俊 詹锋
机构地区 广东省人民医院广东省老年医学研究所中医科
出处 《中药材》 CAS CSCD 北大核心 2012年第3期507-509,共3页 Journal of Chinese Medicinal Materials
基金 广东省中医药管理局项目(20111108)
关键词 补肾通络方 糖尿病肾病 结缔组织生长因子 基质金属蛋白酶
分类号 R969.4 [医药卫生—药理学]
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参考文献7

  • 1Thomason SE, Mclennan SV, Kirwan PD, et al. Renal con- nective tissue growth factor correlates with glomerular base- ment membrane thickness and prospective albuminuria in a non-human primate model of diabetes:possible predictive marker for incipient diabetic nephropathy [J]. J Diabetes Complication~ ,2008,22(4) :284-294.
  • 2Tam FW, Riser BL, Meeran K, et al. Urinary monocyte chemoattractant protein-1 ( MCP-1 ) and connective tissue growth factor(CCN2) as prognostic markers for progression of diabetic nephropathy [ J ]. Cytokine, 2009,47 ( 1 ) : 37- 42.
  • 3Nguyen TQ, Tarnow L, Jorsal A, et al. Plasma connective tissue growth factor is an independent predictor of end- stage renal disease and mortality in type 1 diabetic ne- phropathy [J]. Diabetes Care,2008,31(6) :1177-1182.
  • 4Cornish TC, Baqnasco SM, Macgregor AM, et al. Glomeru- lar protein levels of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 are lower in diabetic sub- jects [J]. J Histochem Cytochem, 2009, 57 ( 11 ) : 995- 1001.
  • 5Nquyen TQ, Roestenberg P, Nieuwenhoven, et al. CTGF in- hibits BMP-7 signaling in diabetic nephropathy [J]. J Am Soc Nephro ,2008,19 ( 11 ) :'2098-2107.
  • 6闵存云.牡丹皮对糖尿病患者CRP、TNF、IL-6的影响[J].中药材,2009,32(9):1490-1492. 被引量：8
  • 7闵存云,王昌俊,詹锋.补肾通络方防治糖尿病肾病的临床观察[J].中药材,2010,33(12):1976-1979. 被引量：9

二级参考文献16

  • 1李世林.牡丹皮镇痛抗炎作用的实验研究[J].中国中医基础医学杂志,2006,12(1):40-41. 被引量：19
  • 2曾文涛,王东,傅茜,陈连周,吴夏枫,王长希.糖尿病患者血清超敏C反应蛋白、白细胞介素-6及白细胞介素-10的变化[J].实用医学杂志,2006,22(17):1995-1997. 被引量：4
  • 3闵存云,刘和强,詹锋,丘伟钟.牡丹皮对糖尿病大鼠PGI_2、TXA_2、ET、NO的影响[J].中药材,2007,30(6):687-690. 被引量：12
  • 4Frank B. Hu, James B. Inflammatory Markers and Risk of Developing Type 2 Diabetes in Women [ J ]. Diabetes, 2004,53 : 693-700.
  • 5Michael B. , Clearfield DO. C-Reactive Protein: New Risk Assessment Tool for Cardiovascular Disease [ J ]. AOA, 2005, 105 (9) :409-416.
  • 6Agata Kubaszek, Jussi Pihlajamaki, Vladislav Komarovski, et al. Promoter polymorphisms of the TNF-α (G- 308A) and IL-6(C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study [J]. Diabetes, 2003,52 (7) : 1872-1876.
  • 7Miyata T. Novel mechanisms and therapeutic options in diabetic nephropathy [J]. Pol. Arch. Med. Wewn. , 2009, 119(4) :261-264.
  • 8Navarro-Gonzalez JF, Mora-Femandez C. The role of inflammatory cytokines in diabetic nephropathy[J]. J. Am. Soc. Nephro. , 2008,19(3) :43342.
  • 9Michael B. Clearfield. C-Reactive Proreiu: New Risk Assessment Tool for Cardiovascular Disease [ J ]. AOA,2005, 9:409-416.
  • 10Moriwaki Y, Inokuchi T, Yamamoto A,et al. Effect of TNF- alpha inhibition on urinary albumin excretion in experimental diabeic rats [ J ]. Acta. Doabetol. , 2007,44 (4) : 215- 218.

共引文献14

同被引文献59

  • 1孟祥雷.中西医结合治疗老年2型糖尿病临床价值探究[J].内蒙古中医药,2023,42(4):35-37. 被引量：3
  • 2中华医学会糖尿病学分会.中国2型糖尿病防治指南[M].北京:北京大学医学出版社,2011:15-16.
  • 3Niewezas MA, Fieoeiello LH, Johnson AC, et al. Serum con- centrations of markers of TNF-alpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes [J]. Clin J Am Soc Nephrol , 2009 , 4 ( 1 ) : 62-70.
  • 4Ilona Idasiak-Piechocka, Andrzej Oko, Elzbieta Pawliczak, et al. Urinary excretion of soluble tumour necrosi sfactor re- ceptor 1 as a marker of increased risk ofprogressive kidney function deterioration in patients with primary chronicglo- merulonephritis [J]. Nephrol Dial Transplant, 2010, 25 (6) :3948-3956.
  • 5Ng DP,Fukushima M,Tai BC,et al. Reduced GFR and al- buminuria in Chinese type 2 diabetes mellitus patients are both independently associated with activation of the TNF- alpha system [ J ]. Diabetologia, 2008,51 ( 12 ) : 2318-2324.
  • 6Navarro-Gonzalez JF, Jarque A, Muros M, et al. Tumor nec- rosis factor-alpha as a therapeutic target for diabetic ne- phropathy [ J ]. Cytokine Growth Factor Rev, 2009,20 ( 2 ) : 165-173.
  • 7Thomas A Wynn, Luke Barron. Macrophages : Master Regu- lators of Inflammation and Fibrosis [ J ]. Semin Liver Dis, 2010,30(3) :245-257.
  • 8Bo Jiao, Yunshan, Yanna, et al. VaIsartan attenuated oxida-tive stress, decreased MCP-1 and TGF-/3 expression in glo- merular mesangial and epithelial cells induced by high-glu- cose levels [ J ]. BioScience Trends, 2011,5 ( 4 ) : 173-181.
  • 9郑莜萸.中药新药治疗糖尿病的临床研究指导原则[S].北京:中国医药科技出版社,2002:233-237.
  • 10Miyata T. Novel mechanisms and therapeutic options in diabetic nephropathy[ J]. Pol Arch Med Wewn,2009, 119 (4) :261 - 264.

引证文献9

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中药材
2012年 第3期

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