摘要
目的:探讨珍菊降压片联合氨氯地平片对肾性高血压大鼠(RHR)血压和血浆内皮素(ET-1)、一氧化氮(NO)的影响。方法:建立两肾一夹肾性高血压大鼠模型,给予肾性高血压大鼠灌服珍菊降压片及氨氯地平片4周,尾袖法测量大鼠尾动脉收缩压,应用放射免疫法及硝酸还原酶法检测肾性高血压大鼠ET-1、NO水平。结果:珍菊降压片联合氨氯地平片降压效果良好,且能明显升高肾性高血压大鼠NO水平及降低ET-1。结论:珍菊降压片联合氨氯地平片较单用氨氯地平片可以明显升高NO水平及降低ET-1,更好的控制肾性高血压大鼠血压。
Objective：To study Zhenjvjiangya tablet combined with Amlodipine tablet on blood pressure and endothelial function in renal hypertensive rat（RHR）.Methods：The two-kidney and one-clip rat method was established.The tail artery blood pressure and plasma endothelin,nitric oxide level were measured after administration with Zhenjvjiangya tablet and Amlodipine tablet.Results：Effect of Zhenjvjiangya tablet combined with Amlodipine tablet on blood pressure is remarkable,and can increase the nitri coxide level and decrease endothelin.Conclusion：Zhenjvjiangya tablet combined with Amlodipine tablet can obviously reduce the blood pressure,increas the nitric oxide level and decrease endothelin.
出处
《中国医药导刊》
2012年第2期286-287,共2页
Chinese Journal of Medicinal Guide
基金
沧州市科技局立项课题(编号:08ZD247)
关键词
高血压
内皮素
一氧化氮
珍菊降压片
氨氯地平片
Hypertension
Endothelin-1
Nitric oxide
ZhenjuJiangyaTablet
Amlodipine tablet
