期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

HCN通道在生物胃肠道起搏机制中作用研究现状 被引量：2

Research on the Function of HCN Channels in Pace-making Mechanisms of Biological Gastrointestinal Tract
原文传递
导出
摘要 HCN通道(hyperpolarization-activated cyclic nucleotide-gated channels)是一种超极化激活的,钠、钾、钙离子混合通透的,直接受cAMP调控的离子通道,在人体内的分布具有一定的组织和细胞特异性,其不仅与神经系统疾病联系紧密,与胃肠道动力障碍疾病也存在一定联系。对HCN通道生理功能、在胃肠起搏电流形成中作用及与疾病的关系的深入了解,必将对今后的研究以及临床治疗有实际意义。 Hyperpolarization-activated cyclic nucleotide-gated channels are hyperpolarization-activated ion channels which can be regulated directly by cAMP and penetrated by Na＋,Ka＋ and Ca2＋.The distribution of the HCN channels in human body shows certain specificities in tissues and cells.They are not only in close relevance with nerve system diseases,but also in connection with gastrointestinal motility diseases.A deepgoing understanding of the physiological functions of HCN channels、the role in the formation of pacemaker current and relation with diseases will undoubtedly have practical significance for the researches and clinical treatments in the future.
作者 徐纯 王景杰
机构地区 第四军医大学唐都医院消化内科
出处 《现代生物医学进展》 CAS 2012年第10期1992-1994,1961,共4页 Progress in Modern Biomedicine
关键词 超极化激活环核苷酸门控阳离子通道 胃肠道 起搏电流 ICC Hyperpolarization-activated cyclic nucleotide-gated channels Gastrointestinal tract Pacemaker current Interstitial cel-ls of Cajal
分类号 Q593 [生物学—生物化学] R333 [医药卫生—人体生理学]
  • 相关文献

参考文献27

  • 1Robinson RB,Siegelbaum SA. Hyperpolarization-activated cation currents: from molecules to physiological function [J]. Annu Rev Physiol, 2003, 65:453-480.
  • 2Noam Y, Bernard C, Baram TZ. Towards an integrated view of HCN channel role in epilepsy [J]. Curr Opin Neurobiol, 2011, 20 [Epub ahead of print].
  • 3Page HC, Munsch T. Modulation of the hyperpolarization-activated cation current of rat thalamie relay neurons by intracellular pH [J]. J Physiol, 1999, 519:493-504.
  • 4Beaumont V, Zucker RS. Enhancement of Synaptic Transmission by Cyclic AMP Modulation of Presynaptic lh Channels [J]. Nat Neurosci, 2000, 3(2): 133-141.
  • 5Poolos NP,Migliore M,Johnston D. Pharmacologicat Upregulation of H-channels Reduces the Excitability of Pyramidal Neuron Dendrites[J]. Nat Neurosci, 2002, 5(8): 767-774.
  • 6Stevens DR, Seifert R, Bufe B, et al. Hyperpolarization-activated Channels HCN1 and HCN4 Mediate Responses to Sour Stimuli [J]. Nature, 2001, 413:631-635.
  • 7Ying S-W, Jia F, Abbas SY, et al. Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons [J]. J Neurosci, 2007,27:8719-8732.
  • 8Poller WC, Bernard R, Derst C, et al. Lateral habenular neurons projecting to reward-processing monoaminergic nuclei express hyperpolarization-activated cyclic nucleotid-gated cation channels[J]. Neuroscience, 2011,124 [Epub ahead of print].
  • 9萧永福,Natalie Chandler,Halina Dobrzynski,Eric S.Richardson,Erica M.TenBroek,Joshua J.Wilhelm,Vinod Sharma,Anthony Varghese,Mark R.Boyett,Paul A.Iaizzo,Daniel C.Sigg.人HCN4通道的滞后现象:影响窦房结起搏的潜在决定因素(英文)[J].生理学报,2010,62(1):1-13. 被引量：10
  • 10Accili EA,Proenza C,Baruscottil M,et al. From funny current to HCN channels :20 years of excitation [J]. News physiol Sci, 2002m 17:32.

二级参考文献61

  • 1Santoro B, Grant SG, Bartsch D ,et al. Interactive cloning with the SH3 domain of N2src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels [J]. Proc Natl Acad Sci, 1997,94 : 14815 - 14820.
  • 2陈艳明.离子通道学[M].湖北:湖北科学技术出版社,2007:84-90.
  • 3Moosmang S, Stieber J, Zong X, et al. Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues [ J ]. Eur J Biochem .2001,268 : 1646 - 1652.
  • 4Zong X,Stieber J,Ludwig A,et al. A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2 [J]. J Biol Chem ,2001,276 ( 9 ) :6313 - 6319.
  • 5Ward SM,Burns AJ,Torihashi S, et al. Mutation of the proto-on-cogene c-kit blocks development of interstitial cells and electrical rhythmicity in routine intestine[J]. J Physiol, 1994,480( Pt 1 ) : 91 - 97.
  • 6Huizinga JD, Thuneberg L, Kluppel M, Malysz J, et al. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activlty[J]. Nature,1995,373(6512) :347 -349.
  • 7Lee JC, Thuneberg L, Berezin I ,et al. Generation of slow waves in membrane potential is an intrinsic property of interstitial cells of Cajal[J]. Am J Physiol,1999,277(2 Pt 1 ) :G409 -423.
  • 8Ibba-Manneschi L, Pacini S, Corsani L, et al. Interstitial cells of Cajal in the human stomach:distribution and relationship with enteric innervation [ J ]. Histol Histopathol,2004,19 ( 4 ) : 1153 - 1164.
  • 9Koh SD, Kim TW, Jun JY,et al. Regulation of pacemaker currents in interstitial ceils of Cajal from murine small intestine by cyclic nucleotides [ J ]. J Physiol,2000,527 ( 1 ) :149 - 162.
  • 10Ward SM,Sanders KM. Physiology and pathophysiology of the in terstitial cell of Cajal : from bench to bedside [J]. Am J Physiol Gastrointest Liver Physiol,2001,281 ( 3 ) :602 - 611.

共引文献18

同被引文献11

引证文献2

二级引证文献31

现代生物医学进展
2012年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部