摘要
目的 探寻前列腺组织中一氧化氮 (NO)水平与年龄之间的关系。方法 应用分光光度法测定 2、6、12月龄各 6只大鼠前列腺组织中的NO水平。结果 2、6、12月龄大鼠前列腺组织中NO水平分别为 :46 48± 7 16 μmol/L、2 7 2 6± 5 83μmol/L、2 3 83± 10 2 1μmol/L ,随着月龄增长 ,NO水平逐渐下降 ,三者间有显著性差异 (P <0 0 5 )。结论 前列腺组织中NO水平与年龄有关 ,NO水平随着年龄的增长而下降。前列腺组织中L 精氨酸 一氧化氮 环磷酸鸟苷 (L ARG NO cGMP)系统缺陷可能正是老年性良性前列腺增生症 (BPH)的发病原因之一。
Objective To research on the relation between the age and the nitric oxide concentration in prostatic tissue of rat.Methods We used spectrophotometry to measure the NO levels in rats normal prostatic tissue with six rats of two,six and twelve months respectively.Results In two ,six and twelve month old rats,the NO levels in prostatic tissue were 46 48±7 16μmol/L,27 26±5 83μmol/L,23 83±10 21μmol/L.The NO levels decreased with the advance of age,and there were significant differences in the three groups(P<0 05).Conclusion The NO levels in rats’ prostates are relative to rats’ age.The NO levels decreased with the advance of age.The defect of L ARG NO cGMP system in prostatic tissue is one of the causes in development of BPH.
出处
《江苏医药》
CAS
CSCD
2000年第6期435-436,共2页
Jiangsu Medical Journal
关键词
前列腺增生
分光光度法
一氧化氮
病理生理
Benign prostatic hyperplasia Nitric oxide Spectrophotometry Rat Bladder outlet obstruction
