摘要
目的通过颞叶癫痫术后单药应用奥卡西平与卡马西平的对比研究,评价两者在疗效、不良反应方面的差异。方法将363例颞叶癫痫术后患者按治疗用药分为奥卡西平组209例和卡马西平组154例。观察2组术后2年癫痫的控制效果及术后药物不良反应发生情况,并进行对比分析。结果奥卡西平组术后癫痫控制效果略高于卡马西平组,但差异无统计学意义(P>0.05)。奥卡西平组不良反应发生率为7.7%,明显低于卡马西平组的14.9%,差异有统计学意义(P<0.05)。结论颞叶癫痫术后单用奥卡西平的癫痫控制效果与卡马西平相同,但不良反应发生率明显低于卡马西平。
Objective To assess the efficacy and side effect of CBZ （Carbamazepine） and OXC （Oxcarbazepine） af- ter temporal lobe epilepsy surgery. Methods 363 patients with temporal lobe epilepsy surgery were randomly divided into CBZ group （ 154 cases） and OXC group （209 cases）. All patients had been followed up 2 years in order to investigate the surgery outcomes and the efficacy and side effect were observed. Results Postoperative seizure control effect in Oxcarbazepine group was slightly higher than that of the carbamazepine group, but the difference was not statistically significant （ P 〉 0.05 ）. The incidence of adverse reactions rate in Oxcarbazepine group was 7.7%, significantly lower than that in the carbamazepine group （ 14.9% ）, and the difference was statistically significant （P 〈 0.05）. Conclusion Both CBZ and OXC are effective in trea- ting the patients after the temporal lobe epilepsy surgery,but the OXC has fewer side effect than the CBZ.
出处
《临床合理用药杂志》
2012年第14期16-18,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
奥卡西平
卡马西平
颞叶癫痫手术
癫痫控制
不良反应
Oxcarbazepine
Carbamazepine
Operation temporal lobe epilepsy
Seizure control
Adverse reaction
