摘要
目的探讨慢性阻塞性肺疾病(COPD)与肺癌的关系。方法对甘肃地区2008年～2011年肺癌组223例及对照组235例进行对照分析。结果有慢性支气管炎、肺气肿、COPD、肺结核患者,肺癌发生的OR值增高,分别为1.80、1.95、2.56、2.12。家族肺癌史及家族COPD病史肺癌发生的OR值明显增高,分别为2.65、2.06。FEV1<80%时,肺癌发生的OR值为1.85。有COPD病史肺癌患者与单纯肺癌患者相比,肺鳞癌发生的OR值明显增高为2.14,临床分期中Ⅲ+Ⅳ期比例明显增高OR值为6.94。结论有COPD病史及COPD家族史的患者,肺癌发生的风险明显增高。肺功能的损伤增加了肺癌的发生率。有COPD病史肺癌患者肺鳞癌发生率较高,且具有临床分期晚的特点。
【Objetive】To explore the relationship between chronic obstructive pulmonary diseases（COPD） and lung cancer.【Methods】The analysis was based on data of a case-control study conducted during the period from 2008 to 2011 in Gansu,China,and was evaluated by the odds ratio（OR）.【Results】The patients with respiratory disease had an increased risk of lung cancer,OR=1.8 for chronic bronchitis,OR=1.95 for emphysema,OR=2.56 for COPD and OR=2.12 for tuberculosis.The patients with family history had an increased risk of lung cancer,OR=2.65 for family history of lung cancer and OR=2.07 for family history of COPD,when FEV1 was lower than 80%,the risk of lung cancer increased（OR=1.85）.The patients with COPD had an increased risk of squamous cell lung cancer（OR=2.14） and clinical staging in stage Ⅲ＋Ⅳ were significantly increased（OR=6.94）.【Conclusion】The patients with history of COPD and family history of COPD have an increased risk of lung cancer,and the impairment of lung function is suggested to increase the risk of lung cancer.Lung cancer patients with a history of COPD,a higher incidence of lung squamous cell carcinoma,and had the characteristics of late clinical stage.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2012年第12期68-71,共4页
China Journal of Modern Medicine
基金
甘肃省自然科学基金资助项目(No:1010RJZA097)
